The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Single helix bin
".
FunFam 6: Regulatory protein SIR4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P11978 (/IPI) P11978 (/IPI) P11978 (/IPI) |
|
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
|
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of chromatin silencing involved in replicative cell aging GO:0001308
The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
|
3 | P11978 (/IGI) P11978 (/IGI) P11978 (/IGI) |
|
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Positive regulation of heterochromatin assembly GO:0031453
Any process that activates or increases the frequency, rate or extent of heterochromatin formation.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Telomere tethering at nuclear periphery GO:0034398
The process in which a telomere is maintained in a specific location at the nuclear periphery.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Establishment of chromatin silencing at silent mating-type cassette GO:0035389
The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Establishment of protein-containing complex localization to telomere GO:0097695
The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Chromatin silencing at subtelomere GO:0099114
Repression of transcription of subtelomeric DNA by altering the structure of chromatin.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
3 | P11978 (/IMP) P11978 (/IMP) P11978 (/IMP) |
|
Chromatin silencing complex GO:0005677
Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
|
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
|
3 | P11978 (/IDA) P11978 (/IDA) P11978 (/IDA) |
