The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Single helix bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: cGMP-dependent protein kinase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CGMP-dependent protein kinase activity GO:0004692
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
12 P0C605 (/IDA) P0C605 (/IDA) Q03043 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P0C605 (/IPI) P0C605 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI) Q13976 (/IPI)
(1 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
9 Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
9 Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
4 O77676 (/ISS) P00516 (/ISS) P0C605 (/ISS) P0C605 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P0C605 (/IDA) P0C605 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P0C605 (/ISO) P0C605 (/ISO)
CGMP-dependent protein kinase activity GO:0004692
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
2 P0C605 (/ISO) P0C605 (/ISO)
CGMP-dependent protein kinase activity GO:0004692
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
2 O77676 (/ISS) P00516 (/ISS)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
2 P0C605 (/ISO) P0C605 (/ISO)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
2 P0C605 (/IDA) P0C605 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P0C605 (/ISO) P0C605 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P0C605 (/ISO) P0C605 (/ISO)
Mitogen-activated protein kinase p38 binding GO:0048273
Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
2 P0C605 (/ISO) P0C605 (/ISO)
CGMP-dependent protein kinase activity GO:0004692
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
1 P00516 (/TAS)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
9 Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
9 Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
9 Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
9 Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP)
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
9 Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP) Q13976 (/IMP)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
9 Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
Negative regulation of vascular associated smooth muscle cell migration GO:1904753
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
9 Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
4 O77676 (/ISS) P00516 (/ISS) P0C605 (/ISS) P0C605 (/ISS)
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
4 O77676 (/ISS) P00516 (/ISS) P0C605 (/ISS) P0C605 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 P0C605 (/IDA) P0C605 (/IDA) Q03043 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 P0C605 (/IMP) P0C605 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P0C605 (/IDA) P0C605 (/IDA)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of inositol phosphate biosynthetic process GO:0010920
Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of glutamate secretion GO:0014050
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
2 P0C605 (/ISO) P0C605 (/ISO)
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
2 P0C605 (/IMP) P0C605 (/IMP)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
2 P0C605 (/IMP) P0C605 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 P0C605 (/IMP) P0C605 (/IMP)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
2 P0C605 (/ISO) P0C605 (/ISO)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of heart contraction GO:0045822
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of smooth muscle contraction GO:0045986
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
2 P0C605 (/IMP) P0C605 (/IMP)
Relaxation of vascular smooth muscle GO:0060087
A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
2 P0C605 (/IMP) P0C605 (/IMP)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
2 P0C605 (/ISO) P0C605 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
2 P0C605 (/ISO) P0C605 (/ISO)
Positive regulation of large conductance calcium-activated potassium channel activity GO:1902608
Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
2 P0C605 (/ISO) P0C605 (/ISO)
Negative regulation of vascular associated smooth muscle cell migration GO:1904753
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
2 P0C605 (/ISO) P0C605 (/ISO)
Regulation of testosterone biosynthetic process GO:2000224
Any process that modulates the frequency, rate or extent of testosterone biosynthetic process.
2 P0C605 (/ISO) P0C605 (/ISO)
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
1 Q03043 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 Q03043 (/IMP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 Q03043 (/TAS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q03043 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 Q03043 (/IMP)
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
1 Q03043 (/IMP)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
1 Q03043 (/IDA)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 Q03043 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 Q03043 (/TAS)
Regulation of response to food GO:0032095
Any process that modulates the frequency, rate or extent of a response to a food stimulus.
1 Q03043 (/IMP)
Habituation GO:0046959
A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
1 Q03043 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P00516 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS) Q13976 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 Q03043 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA) Q13976 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O77676 (/ISS) P00516 (/ISS) P0C605 (/ISS) P0C605 (/ISS)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
2 P0C605 (/ISO) P0C605 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P0C605 (/ISO) P0C605 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P0C605 (/ISO) P0C605 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 P0C605 (/IDA) P0C605 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 P0C605 (/ISO) P0C605 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P0C605 (/ISO) P0C605 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P0C605 (/IMP) P0C605 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P0C605 (/ISO) P0C605 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P0C605 (/ISO) P0C605 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q03043 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q03043 (/IDA)
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