The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Single helix bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Death-associated protein kinase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
5 Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
5 Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI) Q9UIK4 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q8VDF3 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q8VDF3 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q8VDF3 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q8VDF3 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8VDF3 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
5 Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
5 Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
5 Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
5 Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS)
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
5 Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
5 Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS) Q9UIK4 (/TAS)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
5 Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP)
Positive regulation of eosinophil chemotaxis GO:2000424
Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis.
5 Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
5 Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP) Q9UIK4 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q8VDF3 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q8VDF3 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q8VDF3 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q8VDF3 (/ISS)
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
1 Q8VDF3 (/ISO)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q8VDF3 (/ISO)
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
1 Q8VDF3 (/IMP)
Positive regulation of eosinophil chemotaxis GO:2000424
Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis.
1 Q8VDF3 (/ISO)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q8VDF3 (/ISO)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q8VDF3 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
10 A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
10 A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) A0A024R603 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA) Q9UIK4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VDF3 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VDF3 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8VDF3 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8VDF3 (/ISO)
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