The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 2: troponin I, fast skeletal muscle
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
27 |
P02646 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
P19237 (/IPI)
(17 more) |
Troponin T binding GO:0031014
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
|
8 | P02643 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P48788 (/IPI) P48788 (/IPI) P48788 (/IPI) |
Troponin C binding GO:0030172
Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.
|
5 | P08057 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
4 | P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) |
Calcium channel inhibitor activity GO:0019855
Stops, prevents, or reduces the activity of a calcium channel.
|
4 | P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
4 | P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
4 | P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
4 | P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
4 | P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) P19429 (/IPI) |
Troponin T binding GO:0031014
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
|
3 | P13412 (/ISO) P48787 (/ISO) P48787 (/ISO) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Calcium channel inhibitor activity GO:0019855
Stops, prevents, or reduces the activity of a calcium channel.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Troponin C binding GO:0030172
Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P08057 (/IDA) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | P08057 (/IDA) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | P08057 (/IDA) |
There are 37 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
|
21 |
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
(11 more) |
Regulation of striated muscle contraction GO:0006942
Any process that modulates the frequency, rate or extent of striated muscle contraction.
|
14 |
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
P19237 (/NAS)
(4 more) |
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
|
6 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) Q9WUZ5 (/IMP) Q9WUZ5 (/IMP) |
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
5 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P23693 (/IMP) |
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
4 | P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) |
Regulation of systemic arterial blood pressure by ischemic conditions GO:0001980
The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.
|
4 | P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
4 | P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) |
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
|
4 | P13413 (/IDA) P27768 (/IDA) P48787 (/IDA) P48787 (/IDA) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
4 | E7F5J9 (/IMP) F8W417 (/IMP) F8W4T8 (/IMP) Q5PR62 (/IMP) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
4 | P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) P19429 (/ISS) |
Regulation of cardiac muscle contraction by calcium ion signaling GO:0010882
Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
|
4 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) |
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
|
4 | A0A2R8RX09 (/IMP) Q0D2W2 (/IMP) Q6IQE4 (/IMP) Q71N42 (/IMP) |
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
|
4 | P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) |
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
|
4 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) |
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
4 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) |
Skeletal muscle contraction GO:0003009
A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
|
3 | P48788 (/IDA) P48788 (/IDA) P48788 (/IDA) |
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
|
3 | P13412 (/ISO) Q9WUZ5 (/ISO) Q9WUZ5 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | P48788 (/IDA) P48788 (/IDA) P48788 (/IDA) |
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
2 | P48787 (/IDA) P48787 (/IDA) |
Regulation of systemic arterial blood pressure by ischemic conditions GO:0001980
The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.
|
2 | P48787 (/IMP) P48787 (/IMP) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
2 | P48787 (/IDA) P48787 (/IDA) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
2 | P48787 (/IMP) P48787 (/IMP) |
Regulation of smooth muscle contraction GO:0006940
Any process that modulates the frequency, rate or extent of smooth muscle contraction.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
|
2 | P48787 (/IDA) P48787 (/IDA) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P48787 (/IDA) P48787 (/IDA) |
Regulation of cardiac muscle contraction by calcium ion signaling GO:0010882
Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Transition between fast and slow fiber GO:0014883
The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.
|
2 | Q9WUZ5 (/IDA) Q9WUZ5 (/IDA) |
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Regulation of calcium ion binding GO:1901876
Any process that modulates the frequency, rate or extent of calcium ion binding.
|
2 | A0A060VX54 (/IDA) D5M8S7 (/IDA) |
Skeletal muscle contraction GO:0003009
A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
|
1 | P13412 (/ISO) |
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
|
1 | P23693 (/TAS) |
Regulation of smooth muscle contraction GO:0006940
Any process that modulates the frequency, rate or extent of smooth muscle contraction.
|
1 | P23693 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P13412 (/ISO) |
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
1 | P23693 (/IDA) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
21 |
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
P19237 (/TAS)
(11 more) |
Troponin complex GO:0005861
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
|
9 | P13413 (/IDA) P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) P19429 (/IDA) P27768 (/IDA) P48788 (/IDA) P48788 (/IDA) P48788 (/IDA) |
Troponin complex GO:0005861
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
|
5 | P13412 (/ISO) P48787 (/ISO) P48787 (/ISO) Q9WUZ5 (/ISO) Q9WUZ5 (/ISO) |
Myofilament GO:0036379
Any of the smallest contractile units of a myofibril (striated muscle fiber).
|
5 | A0A060VX54 (/IDA) A0A060W3E5 (/IDA) A0A060X4F4 (/IDA) A0A060XSD9 (/IDA) D5M8S7 (/IDA) |
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
4 | P19429 (/TAS) P19429 (/TAS) P19429 (/TAS) P19429 (/TAS) |
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
|
4 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) |
Cardiac Troponin complex GO:1990584
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
|
4 | P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) P19429 (/IMP) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P48788 (/IDA) P48788 (/IDA) P48788 (/IDA) |
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
3 | P23693 (/IDA) P48787 (/IDA) P48787 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Cardiac Troponin complex GO:1990584
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
|
2 | P48787 (/ISO) P48787 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P13412 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P23693 (/IDA) |
Troponin complex GO:0005861
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
|
1 | P23693 (/TAS) |
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
1 | P23693 (/IDA) |
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
|
1 | P23693 (/IDA) |
Cardiac myofibril GO:0097512
A cardiac myofibril is a myofibril specific to cardiac muscle cells.
|
1 | P08057 (/IDA) |
Cardiac Troponin complex GO:1990584
A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
|
1 | P08057 (/IDA) |