The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Rho-associated protein kinase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 F1PU60 (/IPI) P70335 (/IPI) Q13464 (/IPI)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q13464 (/NAS) Q63644 (/NAS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q13464 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q13464 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P70335 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q13464 (/TAS)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
1 Q63644 (/IMP)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
1 P70335 (/ISO)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
1 Q13464 (/NAS)
Tau-protein kinase activity GO:0050321
Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.
1 Q13464 (/NAS)
Showing 1 to 10 of 12 entries

There are 114 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q13464 (/IMP) Q63644 (/IMP)
Response to transforming growth factor beta GO:0071559
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
2 P70335 (/IGI) Q63644 (/IGI)
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
1 I3LFH3 (/IGI)
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
1 Q13464 (/ISS)
Epicardial cell to mesenchymal cell transition GO:0003347
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.
1 A0A0R4IVY5 (/IMP)
Apical constriction GO:0003383
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
1 P70335 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q13464 (/TAS)
Smooth muscle contraction GO:0006939
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
1 Q13464 (/TAS)
Showing 1 to 10 of 114 entries

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
4 O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 P70335 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q13464 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 F1MF50 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13464 (/TAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 P70335 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70335 (/IDA)
Showing 1 to 10 of 14 entries
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