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CATH Superfamily 1.20.200.10

Fumarase/aspartase (Central domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Fumarase/aspartase (Central domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Tyrosine ammonia-lyase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tyrosine ammonia-lyase. [EC: 4.3.1.23]
L-tyrosine = trans-p-hydroxycinnamate + ammonia.
  • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.24 and EC 4.3.1.25.
  • Far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides.
  • Formerly EC 4.3.1.5.
 7 A0A0K1EJ43 A0A0K1EJ43 B8ZV93 B8ZV94 Q0VZ68 Q0VZ68 Q3IWB0
Tyrosine 2,3-aminomutase. [EC: 5.4.3.6]
L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate.
    		 6 A0A0K1EJ43 A0A0K1EJ43 B8ZV93 B8ZV94 Q0VZ68 Q0VZ68
    Phenylalanine ammonia-lyase. [EC: 4.3.1.24]
    L-phenylalanine = trans-cinnamate + ammonia.
    • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 and EC 4.3.1.23 and EC 4.3.1.25.
    • The enzyme from some species is highly specific for phenylalanine.
    • Formerly EC 4.3.1.5.
    		 5 A0A1W5CM86 A0A1W5CM86 B2J528 Q3M5Z3 Q3M5Z3
    Histidine ammonia-lyase. [EC: 4.3.1.3]
    L-histidine = urocanate + NH(3).
    • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25.
    • Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.
    		 1 Q9EWW1
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