The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
ABC transporter type 1, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 83: phosphatidylcholine translocator ABCB4 isoform X7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P43245 (/IPI) Q08201 (/IPI)
Phosphatidylcholine transporter activity GO:0008525
Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 P21440 (/ISO)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
1 P21440 (/ISO)
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
1 P21440 (/ISO)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cholesterol transport GO:0032376
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Positive regulation of phospholipid translocation GO:0061092
Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Cellular response to bile acid GO:1903413
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Positive regulation of phospholipid transport GO:2001140
Any process that activates or increases the frequency, rate or extent of phospholipid transport.
3 P21440 (/ISS) P23174 (/ISS) Q08201 (/ISS)
Bile acid secretion GO:0032782
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
2 P23174 (/ISS) Q08201 (/ISS)
Response to fenofibrate GO:1901557
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus.
2 P23174 (/ISS) Q08201 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P43245 (/IEP)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 P43245 (/IEP)
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
1 O93437 (/NAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P43245 (/IEP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 P43245 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 O93437 (/IDA)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
1 O93437 (/IDA)
Response to mycotoxin GO:0010046
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.
1 P43245 (/IEP)
Response to ionizing radiation GO:0010212
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
1 P43245 (/IEP)
Establishment of endothelial blood-brain barrier GO:0014045
Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
1 P43245 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P43245 (/IEP)
Positive regulation of cholesterol transport GO:0032376
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P21440 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P43245 (/IEP)
Bile acid secretion GO:0032782
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
1 P21440 (/IMP)
Response to vitamin A GO:0033189
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
1 P43245 (/IEP)
Response to genistein GO:0033595
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.
1 P43245 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q08201 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P43245 (/IMP)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
1 P21440 (/ISO)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 P43245 (/IEP)
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
1 P43245 (/IEP)
Embryonic organ development GO:0048568
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 O93437 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q08201 (/IEP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
1 P21440 (/ISO)
Positive regulation of phospholipid translocation GO:0061092
Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
1 P21440 (/ISO)
Sertoli cell barrier remodeling GO:0061843
The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle.
1 P43245 (/IMP)
Cellular response to external biotic stimulus GO:0071217
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
1 P43245 (/IEP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 P43245 (/IEP)
Response to antineoplastic agent GO:0097327
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.
1 P43245 (/IEP)
Response to fenofibrate GO:1901557
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus.
1 P21440 (/IDA)
Cellular response to bile acid GO:1903413
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.
1 P21440 (/ISO)
Response to glycoside GO:1903416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.
1 P43245 (/IEP)
Positive regulation of phospholipid transport GO:2001140
Any process that activates or increases the frequency, rate or extent of phospholipid transport.
1 P21440 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 P43245 (/IDA) Q08201 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P21440 (/ISS) P23174 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P21440 (/ISS) P23174 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P43245 (/IDA) Q08201 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P21440 (/ISS) P23174 (/ISS)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 P21440 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P21440 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P21440 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P21440 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P21440 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P21440 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P21440 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P21440 (/ISO)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 P21440 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P21440 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P21440 (/ISO)
Intercellular canaliculus GO:0046581
An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
1 P21440 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...