The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"ABC transporter type 1, transmembrane domain
".
FunFam 10: Multidrug resistance-associated ABC transporter
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
11 |
Q54JR2 (/IGC)
Q54K24 (/IGC)
Q54LE6 (/IGC)
Q54NL1 (/IGC)
Q54P13 (/IGC)
Q54U44 (/IGC)
Q54V86 (/IGC)
Q54VJ0 (/IGC)
Q8ST87 (/IGC)
Q8T6H3 (/IGC)
(1 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P53049 (/IPI) P53049 (/IPI) P53049 (/IPI) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | Q581W6 (/ISM) Q583D4 (/ISM) Q95PL4 (/ISM) |
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
|
3 | P53049 (/IDA) P53049 (/IDA) P53049 (/IDA) |
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
|
3 | P53049 (/IMP) P53049 (/IMP) P53049 (/IMP) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
3 | Q581W6 (/ISM) Q583D4 (/ISM) Q95PL4 (/ISM) |
Organic anion transmembrane transporter activity GO:0008514
Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
2 | Q96J66 (/IDA) Q96J66 (/IDA) |
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
|
2 | P38735 (/ISA) P38735 (/ISA) |
Purine nucleotide transmembrane transporter activity GO:0015216
Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other.
|
2 | Q96J66 (/IDA) Q96J66 (/IDA) |
ATPase-coupled monocarboxylic acid transmembrane transporter activity GO:0033285
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out).
|
2 | P32386 (/IMP) P32386 (/IMP) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
1 | Q4QBE9 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Culmination involved in sorocarp development GO:0031154
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
|
5 | Q54JR2 (/IMP) Q54P13 (/IMP) Q54V86 (/IMP) Q54VJ0 (/IMP) Q8T6H3 (/IMP) |
Sorocarp morphogenesis GO:0031288
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.
|
3 | Q54K24 (/IMP) Q54P13 (/IMP) Q54V86 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
3 | Q581W6 (/IMP) Q583D4 (/IMP) Q95PL4 (/IMP) |
Xenobiotic transport GO:0042908
The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | P53049 (/IDA) P53049 (/IDA) P53049 (/IDA) |
Xenobiotic transport GO:0042908
The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | P53049 (/IMP) P53049 (/IMP) P53049 (/IMP) |
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
|
2 | P38735 (/IMP) P38735 (/IMP) |
Organic anion transport GO:0015711
The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
2 | Q96J66 (/IDA) Q96J66 (/IDA) |
Monocarboxylic acid transport GO:0015718
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P32386 (/IMP) P32386 (/IMP) |
Purine nucleotide transport GO:0015865
The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell.
|
2 | Q96J66 (/IDA) Q96J66 (/IDA) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
2 | Q96J66 (/TAS) Q96J66 (/TAS) |
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
|
2 | P38735 (/IGI) P38735 (/IGI) |
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
|
2 | P38735 (/IMP) P38735 (/IMP) |
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
|
1 | Q4QBE9 (/IEP) |
Slug development involved in sorocarp development GO:0031153
The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development.
|
1 | Q54NL1 (/HMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P53049 (/IDA) P53049 (/IDA) P53049 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q581W6 (/ISM) Q583D4 (/ISM) Q95PL4 (/ISM) |
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
|
3 | Q581W6 (/ISM) Q583D4 (/ISM) Q95PL4 (/ISM) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
3 | P53049 (/HDA) P53049 (/HDA) P53049 (/HDA) |
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
2 | P32386 (/IDA) P32386 (/IDA) |
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
|
2 | P38735 (/IDA) P38735 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P38735 (/HDA) P38735 (/HDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | P32386 (/HDA) P32386 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q96J66 (/TAS) Q96J66 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q96J66 (/IDA) Q96J66 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q96J66 (/HDA) Q96J66 (/HDA) |
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
|
1 | Q4QBE9 (/IDA) |