The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cation efflux protein transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: zinc transporter 3 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q8IWU4 (/IPI) Q99726 (/IPI) Q99726 (/IPI) Q99726 (/IPI) Q99726 (/IPI)
ATPase-coupled zinc transmembrane transporter activity GO:0015633
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in).
4 Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
3 P97441 (/TAS) P97441 (/TAS) Q8IWU4 (/TAS)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
2 A0A0R4IFM6 (/ISS) A0A2R8Q4D8 (/ISS)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q8IWU4 (/IDA)
Zinc ion transmembrane transporter activity GO:0005385
Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
1 Q8BGG0 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q8IWU4 (/IC)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8BGG0 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8IWU4 (/ISS)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
4 Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
3 P0CE46 (/IMP) Q8BGG0 (/IMP) Q8IWU4 (/IMP)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
3 P0CE46 (/IMP) Q8BGG0 (/IMP) Q8IWU4 (/IMP)
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
3 P97441 (/ISO) P97441 (/ISO) Q8BGG0 (/ISO)
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
2 A0A0R4IFM6 (/IMP) A0A2R8Q4D8 (/IMP)
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 A0A0R4IFM6 (/ISS) A0A2R8Q4D8 (/ISS)
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P97441 (/TAS) P97441 (/TAS)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
2 P0CE46 (/IMP) Q8BGG0 (/IMP)
Detoxification of zinc ion GO:0010312
Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion.
2 P97441 (/TAS) P97441 (/TAS)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 A0A0R4IFM6 (/IMP) A0A2R8Q4D8 (/IMP)
Sequestering of zinc ion GO:0032119
The process of binding or confining zinc ions such that they are separated from other components of a biological system.
2 P97441 (/TAS) P97441 (/TAS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 A0A0R4IFM6 (/IMP) A0A2R8Q4D8 (/IMP)
Positive regulation of transport GO:0051050
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P97441 (/IGI) P97441 (/IGI)
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
2 P97441 (/TAS) P97441 (/TAS)
Zinc ion import into synaptic vesicle GO:0099180
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
2 P97441 (/IDA) P97441 (/IDA)
Zinc ion import into synaptic vesicle GO:0099180
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
2 P97441 (/IMP) P97441 (/IMP)
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8IWU4 (/IDA)
Zinc ion transport GO:0006829
The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8BGG0 (/ISO)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q8BGG0 (/ISO)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q8IWU4 (/ISS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q8BGG0 (/ISO)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
1 Q8BGG0 (/ISO)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P0CE46 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q8BGG0 (/ISO)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q8IWU4 (/ISS)
Sequestering of zinc ion GO:0032119
The process of binding or confining zinc ions such that they are separated from other components of a biological system.
1 Q8IWU4 (/IDA)
Sequestering of zinc ion GO:0032119
The process of binding or confining zinc ions such that they are separated from other components of a biological system.
1 Q8BGG0 (/ISO)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
1 P0CE46 (/IEP)
Regulation of vesicle-mediated transport GO:0060627
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
1 P0CE46 (/IMP)
Regulation of vesicle-mediated transport GO:0060627
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
1 Q8BGG0 (/ISO)
Regulation of vesicle-mediated transport GO:0060627
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
1 Q8IWU4 (/ISS)
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
1 P0CE46 (/IMP)
Regulation of sequestering of zinc ion GO:0061088
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.
1 Q8IWU4 (/ISS)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P0CE46 (/IEP)

There are 30 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
7 Q08E25 (/ISS) Q5R617 (/ISS) Q6QIX3 (/ISS) Q99726 (/ISS) Q99726 (/ISS) Q99726 (/ISS) Q99726 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
4 Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
4 Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
4 Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA) Q99726 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
4 Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS) Q99726 (/TAS)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
3 Q08E25 (/ISS) Q5R617 (/ISS) Q6QIX3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P97441 (/ISO) P97441 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 P97441 (/ISO) P97441 (/ISO)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
2 P97441 (/ISO) P97441 (/ISO)
Integral component of synaptic vesicle membrane GO:0030285
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P97441 (/IDA) P97441 (/IDA)
Integral component of synaptic vesicle membrane GO:0030285
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P97441 (/IMP) P97441 (/IMP)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
2 P97441 (/IDA) P97441 (/IDA)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
2 P97441 (/TAS) P97441 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 P0CE46 (/IDA) Q8BGG0 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P97441 (/IDA) P97441 (/IDA)
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
2 P97441 (/IDA) P97441 (/IDA)
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
2 P97441 (/IMP) P97441 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P97441 (/IDA) P97441 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P97441 (/IMP) P97441 (/IMP)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q8BGG0 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8IWU4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8BGG0 (/ISO)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 Q8IWU4 (/IDA)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 Q8BGG0 (/ISO)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 Q8IWU4 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q8BGG0 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q8IWU4 (/ISS)
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