The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"NCX, central ion-binding region
".
FunFam 7: Vacuolar calcium ion transporter
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
|
15 |
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
(5 more) |
Calcium:proton antiporter activity GO:0015369
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
|
12 |
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
O34840 (/IDA)
Q75XW3 (/IDA)
Q75XW3 (/IDA)
(2 more) |
Calcium:proton antiporter activity GO:0015369
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
|
2 | Q99385 (/IMP) Q99385 (/IMP) |
Potassium:proton antiporter activity GO:0015386
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
|
2 | Q99385 (/IMP) Q99385 (/IMP) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
17 |
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
(7 more) |
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
10 | O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) Q75XW3 (/IDA) Q75XW3 (/IDA) |
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q99385 (/IMP) Q99385 (/IMP) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
2 | Q99385 (/IMP) Q99385 (/IMP) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
2 | Q99385 (/IDA) Q99385 (/IDA) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
2 | Q99385 (/IMP) Q99385 (/IMP) |
Calcium ion import into vacuole GO:0140146
The directed movement of calcium cations into the vacuole across the vacuolar membrane.
|
1 | O59768 (/NAS) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
15 |
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
C6KSN3 (/IDA)
(5 more) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
15 |
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
C6KSN3 (/ISS)
(5 more) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
10 | O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) O34840 (/IDA) Q75XW3 (/IDA) Q75XW3 (/IDA) |
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
2 | Q99385 (/IDA) Q99385 (/IDA) |
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
|
2 | Q99385 (/HDA) Q99385 (/HDA) |
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
|
2 | Q99385 (/IDA) Q99385 (/IDA) |
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
|
1 | O59768 (/ISO) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | O59768 (/HDA) |