The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"MFS general substrate transporter like domains
".
FunFam 23: Solute carrier family 22 member 6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 33 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
|
17 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
O35956 (/ISS)
(7 more) |
|
Organic anion transmembrane transporter activity GO:0008514
Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
16 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
Q4W8A3 (/ISS)
(6 more) |
|
Organic anion transmembrane transporter activity GO:0008514
Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
7 | O35956 (/IDA) Q4U2R8 (/IDA) Q76M99 (/IDA) Q8VC69 (/IDA) Q8VCA0 (/IDA) Q9NSA0 (/IDA) Q9R1U7 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O35956 (/IPI) Q4U2R8 (/IPI) Q8CFZ5 (/IPI) Q9NSA0 (/IPI) |
|
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
|
3 | Q4U2R8 (/IDA) Q8TCC7 (/IDA) Q9NSA0 (/IDA) |
|
Organic anion transmembrane transporter activity GO:0008514
Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
3 | O88909 (/ISO) Q8VC69 (/ISO) Q8VCA0 (/ISO) |
|
Sodium-independent organic anion transmembrane transporter activity GO:0015347
Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.
|
3 | O35956 (/IDA) Q8IVM8 (/IDA) Q9NSA0 (/IDA) |
|
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
|
2 | O88909 (/ISO) Q8VC69 (/ISO) |
|
Organic anion transmembrane transporter activity GO:0008514
Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
2 | Q4U2R8 (/IMP) Q8VC69 (/IMP) |
|
Urate transmembrane transporter activity GO:0015143
Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.
|
2 | Q8CFZ5 (/IDA) Q96S37 (/IDA) |
Showing 1 to 10 of 33 entries
There are 41 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Alpha-ketoglutarate transport GO:0015742
The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
17 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
O35956 (/ISS)
(7 more) |
|
Organic anion transport GO:0015711
The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
16 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
Q4W8A3 (/ISS)
(6 more) |
|
Renal tubular secretion GO:0097254
Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.
|
16 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
O35956 (/ISS)
(6 more) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
7 | A0A2R8Q000 (/IDA) A0A2R8QCQ4 (/IDA) A7MC17 (/IDA) F1Q880 (/IDA) F1QS93 (/IDA) O35956 (/IDA) Q7T3D2 (/IDA) |
|
Organic anion transport GO:0015711
The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
4 | O35956 (/IDA) Q4U2R8 (/IDA) Q8VCA0 (/IDA) Q9NSA0 (/IDA) |
|
Anion transmembrane transport GO:0098656
The process in which an anion is transported across a membrane.
|
3 | A0A2R8QCQ4 (/IDA) A7MC17 (/IDA) F1QS93 (/IDA) |
|
Organic anion transport GO:0015711
The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
|
2 | Q4U2R8 (/IMP) Q8VC69 (/IMP) |
|
Urate transport GO:0015747
The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q8CFZ5 (/IDA) Q96S37 (/IDA) |
|
Response to methotrexate GO:0031427
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.
|
2 | O35956 (/IEP) Q9R1U7 (/IEP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
2 | Q3ZAV1 (/ISS) Q8CFZ5 (/ISS) |
Showing 1 to 10 of 41 entries
There are 25 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
18 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
O35956 (/ISS)
(8 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
17 |
F7AKP9 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
F7GJJ2 (/ISS)
G1LHR0 (/ISS)
G1QWP8 (/ISS)
G1U0K7 (/ISS)
G3T392 (/ISS)
H0WN28 (/ISS)
O35956 (/ISS)
(7 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | A0A2R8Q000 (/IDA) A0A2R8QCQ4 (/IDA) A7MC17 (/IDA) E7FED9 (/IDA) F1Q880 (/IDA) F1QS93 (/IDA) O35956 (/IDA) Q7T3D2 (/IDA) Q96S37 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q4U2R8 (/TAS) Q8TCC7 (/TAS) Q96S37 (/TAS) Q9NSA0 (/TAS) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
4 | Q4U2R8 (/IDA) Q8IVM8 (/IDA) Q8TCC7 (/IDA) Q9R1U7 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
4 | Q3ZAV1 (/IDA) Q76M99 (/IDA) Q96S37 (/IDA) Q9NSA0 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
4 | Q4U2R8 (/HDA) Q8TCC7 (/HDA) Q96S37 (/HDA) Q9NSA0 (/HDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q4U2R8 (/IDA) Q8VC69 (/IDA) Q9NSA0 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q8CFZ5 (/ISO) Q8VC69 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q3ZAV1 (/ISS) Q8CFZ5 (/ISS) |
Showing 1 to 10 of 25 entries
