CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 6: Interleukin-6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
5 | P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) P20607 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P05231 (/IPI) P05231 (/IPI) P08505 (/IPI) P08505 (/IPI) |
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
|
3 | P08505 (/IDA) P08505 (/IDA) P20607 (/IDA) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
|
2 | P05231 (/IPI) P05231 (/IPI) |
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P20607 (/IDA) |
There are 224 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
|
39 |
A3FBE9 (/ISS)
O35736 (/ISS)
P05231 (/ISS)
P05231 (/ISS)
P20607 (/ISS)
P26892 (/ISS)
P26893 (/ISS)
P29455 (/ISS)
P29455 (/ISS)
P41323 (/ISS)
(29 more) |
Neutrophil apoptotic process GO:0001781
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
|
4 | P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) |
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
4 | B7TXY8 (/TAS) B7TXY8 (/TAS) P29455 (/TAS) P29455 (/TAS) |
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
|
4 | B7TXY8 (/TAS) B7TXY8 (/TAS) P29455 (/TAS) P29455 (/TAS) |
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) |
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
|
4 | B7TXY8 (/TAS) B7TXY8 (/TAS) P29455 (/TAS) P29455 (/TAS) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | P05231 (/IDA) P05231 (/IDA) P20607 (/IDA) |
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
3 | P05231 (/IDA) P05231 (/IDA) P20607 (/IDA) |
Neutrophil apoptotic process GO:0001781
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Neutrophil apoptotic process GO:0001781
Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Myeloid cell homeostasis GO:0002262
The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Hepatic immune response GO:0002384
An immune response taking place in the liver.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Hepatic immune response GO:0002384
An immune response taking place in the liver.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Hepatic immune response GO:0002384
An immune response taking place in the liver.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
|
2 | P05231 (/IC) P05231 (/IC) |
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of acute inflammatory response GO:0002675
Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
2 | P05231 (/IC) P05231 (/IC) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P05231 (/IGI) P05231 (/IGI) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of vascular endothelial growth factor production GO:0010575
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of lipid storage GO:0010888
Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of gliogenesis GO:0014015
Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P05231 (/IMP) P05231 (/IMP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P08505 (/ISO) P08505 (/ISO) |
Response to peptidoglycan GO:0032494
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of collagen biosynthetic process GO:0032966
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Negative regulation of collagen biosynthetic process GO:0032966
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cellular response to hepatocyte growth factor stimulus GO:0035729
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Negative regulation of chemokine biosynthetic process GO:0045079
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Negative regulation of chemokine biosynthetic process GO:0045079
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Negative regulation of chemokine biosynthetic process GO:0045079
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Regulation of circadian sleep/wake cycle, non-REM sleep GO:0045188
Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of interleukin-17 biosynthetic process GO:0045380
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Positive regulation of interleukin-17 biosynthetic process GO:0045380
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
|
2 | P05231 (/NAS) P05231 (/NAS) |
Positive regulation of T-helper 2 cell differentiation GO:0045630
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
|
2 | P05231 (/IC) P05231 (/IC) |
Negative regulation of bone resorption GO:0045779
Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Negative regulation of bone resorption GO:0045779
Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Negative regulation of membrane potential GO:0045837
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
2 | P05231 (/IC) P05231 (/IC) |
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
|
2 | P08505 (/IGI) P08505 (/IGI) |
Negative regulation of hormone secretion GO:0046888
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Negative regulation of muscle organ development GO:0048635
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of transmission of nerve impulse GO:0051971
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Branching involved in salivary gland morphogenesis GO:0060445
The process in which the branching structure of the salivary gland is generated and organized.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Branching involved in salivary gland morphogenesis GO:0060445
The process in which the branching structure of the salivary gland is generated and organized.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664
The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Regulation of astrocyte activation GO:0061888
Any process that modulates the frequency, rate or extent of astrocyte activation.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Glucagon secretion GO:0070091
The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).
|
2 | P08505 (/IMP) P08505 (/IMP) |
Glucagon secretion GO:0070091
The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).
|
2 | P05231 (/ISS) P05231 (/ISS) |
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
2 | P05231 (/IDA) P05231 (/IDA) |
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
2 | P08505 (/IDA) P08505 (/IDA) |
Positive regulation of cell proliferation in bone marrow GO:0071864
A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.
|
2 | P08505 (/IGI) P08505 (/IGI) |
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Positive regulation of extracellular matrix disassembly GO:0090091
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of extracellular matrix disassembly GO:0090091
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Positive regulation of neuroinflammatory response GO:0150078
Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Positive regulation of apoptotic DNA fragmentation GO:1902512
Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.
|
2 | P05231 (/IMP) P05231 (/IMP) |
Positive regulation of apoptotic DNA fragmentation GO:1902512
Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.
|
2 | P08505 (/ISO) P08505 (/ISO) |
Regulation of microglial cell activation GO:1903978
Any process that modulates the frequency, rate or extent of microglial cell activation.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Regulation of maintenance of permeability of blood-brain barrier GO:1905603
Any process that modulates the frequency, rate or extent of maintenance of permeability of blood-brain barrier.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Positive regulation of T-helper 2 cell cytokine production GO:2000553
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Positive regulation of T-helper 2 cell cytokine production GO:2000553
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Negative regulation of interleukin-1-mediated signaling pathway GO:2000660
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.
|
2 | P08505 (/IMP) P08505 (/IMP) |
Negative regulation of interleukin-1-mediated signaling pathway GO:2000660
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.
|
2 | P05231 (/ISS) P05231 (/ISS) |
Positive regulation of type B pancreatic cell apoptotic process GO:2000676
Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.
|
2 | P05231 (/TAS) P05231 (/TAS) |
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
|
1 | P20607 (/IEP) |
Acute inflammatory response GO:0002526
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
|
1 | P20607 (/IEP) |
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
1 | P20607 (/IDA) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P20607 (/IEP) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P20607 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | P20607 (/IDA) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | P20607 (/IEP) |
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
1 | P20607 (/IEP) |
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
1 | P20607 (/IEP) |
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | P20607 (/IEP) |
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
1 | P20607 (/IEP) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P20607 (/IMP) |
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
|
1 | P20607 (/IEP) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | P20607 (/IEP) |
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
|
1 | P20607 (/IEP) |
Lymphocyte costimulation GO:0031294
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.
|
1 | P20607 (/IEP) |
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | P20607 (/IEP) |
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | P20607 (/IEP) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P20607 (/IEP) |
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P20607 (/IEP) |
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P20607 (/IEP) |
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P20607 (/IEP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P20607 (/IEP) |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P20607 (/IDA) |
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | P20607 (/IEP) |
Regulation of circadian sleep/wake cycle, non-REM sleep GO:0045188
Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
|
1 | P20607 (/IMP) |
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | P20607 (/IDA) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
1 | P20607 (/IMP) |
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | P20607 (/IMP) |
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
|
1 | P20607 (/IDA) |
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
|
1 | P20607 (/IMP) |
Negative regulation of membrane potential GO:0045837
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | P20607 (/IMP) |
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
1 | P20607 (/IEP) |
Bone remodeling GO:0046849
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
|
1 | P20607 (/IEP) |
Negative regulation of muscle organ development GO:0048635
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
|
1 | P20607 (/IDA) |
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
|
1 | P20607 (/IDA) |
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | P20607 (/IEP) |
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
1 | P20607 (/IEP) |
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P20607 (/IDA) |
Positive regulation of transmission of nerve impulse GO:0051971
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
|
1 | P20607 (/IDA) |
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P20607 (/IEP) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P20607 (/IDA) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P20607 (/IEP) |
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P20607 (/IEP) |
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | P20607 (/IEP) |
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | P20607 (/IEP) |
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | P20607 (/IEP) |
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
|
1 | P20607 (/IEP) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
1 | P20607 (/IDA) |
Cellular response to prolactin GO:1990646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.
|
1 | P20607 (/IEP) |
Positive regulation of estradiol secretion GO:2000866
Any process that activates or increases the frequency, rate or extent of estradiol secretion.
|
1 | P26893 (/IDA) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
9 | B7TXY8 (/IDA) B7TXY8 (/IDA) P05231 (/IDA) P05231 (/IDA) P08505 (/IDA) P08505 (/IDA) P20607 (/IDA) P29455 (/IDA) P29455 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
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2 | P05231 (/TAS) P05231 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
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2 | P08505 (/ISO) P08505 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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2 | P08505 (/ISO) P08505 (/ISO) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
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2 | P05231 (/TAS) P05231 (/TAS) |
Interleukin-6 receptor complex GO:0005896
A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.
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2 | P05231 (/IDA) P05231 (/IDA) |
Interleukin-6 receptor complex GO:0005896
A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.
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2 | P08505 (/ISO) P08505 (/ISO) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
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2 | P08505 (/IDA) P08505 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
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1 | P26892 (/NAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | P20607 (/IDA) |