The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 105: Leptin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of endothelial cell proliferation GO:0001936
Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
2 Q706D0 (/ISS) Q706D1 (/ISS)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Prostaglandin secretion GO:0032310
The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Interleukin-12 production GO:0032615
The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Interleukin-6 production GO:0032635
The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of natural killer cell activation GO:0032814
Any process that modulates the frequency, rate or extent of natural killer cell activation.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of natural killer cell proliferation GO:0032817
Any process that modulates the frequency, rate or extent of natural killer cell proliferation.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Negative regulation of appetite by leptin-mediated signaling pathway GO:0038108
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of natural killer cell mediated cytotoxicity GO:0042269
Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of bone remodeling GO:0046850
Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Intestinal absorption GO:0050892
Any process in which nutrients are taken up from the contents of the intestine.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Interleukin-6 secretion GO:0072604
The regulated release of interleukin-6 from a cell.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Interleukin-8 secretion GO:0072606
The regulated release of interleukin-8 from a cell.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of brown fat cell differentiation GO:0090335
Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Bone growth GO:0098868
The increase in size or mass of a bone that contributes to the shaping of that bone.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
2 Q706D0 (/ISS) Q706D1 (/ISS)
Activation of protein kinase C activity GO:1990051
Any process that initiates the activity of the inactive enzyme protein kinase C.
2 Q706D0 (/ISS) Q706D1 (/ISS)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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