The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Vinculin, Vh2 four-helix bundle
".
FunFam 2: Vinculin b
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | P12003 (/IPI) P12003 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) Q64727 (/IPI) |
Dystroglycan binding GO:0002162
Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
|
6 | P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
6 | P18206 (/IDA) P18206 (/IDA) P18206 (/IDA) P18206 (/IDA) P18206 (/IDA) P18206 (/IDA) |
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
|
6 | P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) |
Vinculin binding GO:0017166
Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.
|
6 | G3UPE7 (/ISS) H0Z8K6 (/ISS) H9GEN7 (/ISS) U3IR26 (/ISS) U3JX29 (/ISS) U3JX30 (/ISS) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
6 | P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
6 | G3UPE7 (/ISS) H0Z8K6 (/ISS) H9GEN7 (/ISS) U3IR26 (/ISS) U3JX29 (/ISS) U3JX30 (/ISS) |
Alpha-catenin binding GO:0045294
Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
|
6 | P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) P18206 (/IPI) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
6 | P18206 (/HDA) P18206 (/HDA) P18206 (/HDA) P18206 (/HDA) P18206 (/HDA) P18206 (/HDA) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
6 | P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) P18206 (/ISS) |
Showing 1 to 10 of 26 entries
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
11 |
P12003 (/ISS)
P12003 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P26234 (/ISS)
P26234 (/ISS)
(1 more) |
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
|
6 | P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) |
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
6 | P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) |
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
6 | P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
6 | P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) |
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
6 | P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) |
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
6 | P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) P18206 (/TAS) |
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
|
6 | P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) |
Protein localization to cell surface GO:0034394
A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
|
6 | P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) |
Apical junction assembly GO:0043297
The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.
|
6 | P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) P18206 (/IMP) |
Showing 1 to 10 of 32 entries
There are 63 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Outer dense plaque of desmosome GO:0090636
The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane.
|
68 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(58 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
64 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(54 more) |
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
|
64 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(54 more) |
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
|
64 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(54 more) |
Inner dense plaque of desmosome GO:0090637
The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane.
|
64 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(54 more) |
Terminal web GO:1990357
An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.
|
64 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(54 more) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
62 |
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A024QZN4 (/ISS)
A0A091FBY5 (/ISS)
A0A091GA46 (/ISS)
A0A091JDB2 (/ISS)
A0A091L4Y3 (/ISS)
A0A091LBC7 (/ISS)
(52 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
23 |
A0A024QZN4 (/IDA)
A0A024QZN4 (/IDA)
A0A024QZN4 (/IDA)
A0A024QZN4 (/IDA)
A0A024QZN4 (/IDA)
B3DI32 (/IDA)
B8JIH2 (/IDA)
F6NHA0 (/IDA)
P12003 (/IDA)
P12003 (/IDA)
(13 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
17 |
G3UPE7 (/ISS)
H0Z8K6 (/ISS)
H9GEN7 (/ISS)
P12003 (/ISS)
P12003 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
(7 more) |
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
17 |
G3UPE7 (/ISS)
H0Z8K6 (/ISS)
H9GEN7 (/ISS)
P12003 (/ISS)
P12003 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
P18206 (/ISS)
(7 more) |
Showing 1 to 10 of 63 entries