The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Myosin VI head, motor domain, U50 subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Myosin VB

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P21271 (/IPI) P70569 (/IPI) Q9ULV0 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
2 P70569 (/IPI) Q9ULV0 (/IPI)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q9ULV0 (/TAS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P70569 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P21271 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 P21271 (/ISO)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 P70569 (/IPI)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 P21271 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P70569 (/IMP)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P21271 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
3 A0A0R4IPW9 (/IMP) A0A286YAD0 (/IMP) F1QKS0 (/IMP)
Establishment of secretory granule localization GO:0032254
The directed movement of a secretory granule to a specific location.
3 E9Q1F5 (/ISO) Q6P6F3 (/ISO) Q8BWY8 (/ISO)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
3 A0A0R4IPW9 (/IMP) A0A286YAD0 (/IMP) F1QKS0 (/IMP)
Digestive tract morphogenesis GO:0048546
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
3 A0A0R4IPW9 (/IMP) A0A286YAD0 (/IMP) F1QKS0 (/IMP)
Axon development GO:0061564
The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
3 A0A0R4IPW9 (/IMP) A0A286YAD0 (/IMP) F1QKS0 (/IMP)
Intestinal lipid absorption GO:0098856
Any process in which lipids are taken up from the contents of the intestine.
3 A0A0R4IPW9 (/IMP) A0A286YAD0 (/IMP) F1QKS0 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 P21271 (/ISS) P70569 (/ISS)
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
1 Q9ULV0 (/TAS)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P70569 (/IMP)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P21271 (/ISO)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q9ULV0 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 P21271 (/ISO)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
1 Q9ULV0 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
1 P21271 (/ISO)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 P70569 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 P21271 (/ISO)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 P70569 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 P21271 (/ISO)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 P70569 (/IMP)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 P21271 (/ISO)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P21271 (/IDA)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P21271 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 P70569 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 P21271 (/ISO)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 P70569 (/IDA)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 P70569 (/IMP)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 P21271 (/ISO)
Regulation of modification of postsynaptic structure GO:0099159
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
1 P70569 (/IDA)
Regulation of modification of postsynaptic structure GO:0099159
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
1 P70569 (/IMP)
Regulation of modification of postsynaptic structure GO:0099159
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
1 P21271 (/ISO)
Neurotransmitter receptor transport, endosome to plasma membrane GO:0099639
The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
1 P70569 (/IDA)
Neurotransmitter receptor transport, endosome to plasma membrane GO:0099639
The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
1 P70569 (/IMP)
Neurotransmitter receptor transport, endosome to plasma membrane GO:0099639
The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
1 P21271 (/ISO)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 P70569 (/IMP)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 P21271 (/ISO)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 P70569 (/IMP)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 P21271 (/ISO)
Cellular response to glycine GO:1905430
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.
1 P70569 (/IEP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
3 E9Q1F5 (/ISO) Q6P6F3 (/ISO) Q8BWY8 (/ISO)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
2 P21271 (/ISS) P70569 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9NQX4 (/HDA) Q9ULV0 (/HDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
2 P21271 (/IDA) P70569 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
2 P21271 (/IMP) P70569 (/IMP)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 P21271 (/IDA)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
1 Q9ULV0 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9ULV0 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P21271 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P70569 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P21271 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P70569 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P21271 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P70569 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P21271 (/ISO)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
1 Q9ULV0 (/IDA)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
1 P21271 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P70569 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P21271 (/ISO)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P21271 (/ISO)
Postsynaptic actin cytoskeleton GO:0098871
The actin cytoskeleton that is part of a postsynapse
1 P70569 (/IDA)
Postsynaptic actin cytoskeleton GO:0098871
The actin cytoskeleton that is part of a postsynapse
1 P21271 (/ISO)
Postsynaptic recycling endosome membrane GO:0098944
The lipid bilayer surrounding a postsynaptic recycling endosome.
1 P70569 (/IDA)
Postsynaptic recycling endosome membrane GO:0098944
The lipid bilayer surrounding a postsynaptic recycling endosome.
1 P70569 (/IMP)
Postsynaptic recycling endosome membrane GO:0098944
The lipid bilayer surrounding a postsynaptic recycling endosome.
1 P21271 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P70569 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P70569 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P21271 (/ISO)
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