The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Myosin VI head, motor domain, U50 subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: unconventional myosin-Ic isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O00159 (/IPI) Q9WTI7 (/IPI)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q9WTI7 (/EXP)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q63355 (/IDA)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q9WTI7 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9WTI7 (/NAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O00159 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9WTI7 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q63355 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q9WTI7 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q9WTI7 (/NAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9WTI7 (/NAS)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 Q9WTI7 (/TAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q9WTI7 (/IPI)
Ral GTPase binding GO:0017160
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.
1 O00159 (/IPI)
Ral GTPase binding GO:0017160
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.
1 Q9WTI7 (/ISO)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
1 Q63355 (/IDA)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
1 Q9WTI7 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q63355 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q9WTI7 (/ISO)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
5 A0A286Y9H2 (/IMP) A0A2R8Q9G7 (/IMP) A5PF48 (/IMP) E7F5R7 (/IMP) R4GDM7 (/IMP)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
2 O00159 (/IMP) Q9WTI7 (/IMP)
Positive regulation of cellular response to insulin stimulus GO:1900078
Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
2 Q63355 (/IMP) Q9WTI7 (/IMP)
Cranial skeletal system development GO:1904888
The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
2 F1QKT3 (/IMP) F1QZR7 (/IMP)
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
1 O00159 (/IDA)
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
1 Q9WTI7 (/ISO)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 O00159 (/IDA)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q9WTI7 (/ISO)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
1 Q9WTI7 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 O00159 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q9WTI7 (/ISO)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
1 Q63355 (/IMP)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
1 Q9WTI7 (/ISO)
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway GO:0038089
A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
1 O00159 (/IMP)
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway GO:0038089
A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
1 Q9WTI7 (/ISO)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
1 O00159 (/TAS)
Positive regulation of gene expression, epigenetic GO:0045815
Any epigenetic process that activates or increases the rate of gene expression.
1 O00159 (/TAS)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 Q9WTI7 (/IDA)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q9WTI7 (/IDA)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q9WTI7 (/ISO)
Positive regulation of cellular response to insulin stimulus GO:1900078
Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
1 Q9WTI7 (/IDA)
Positive regulation of cellular response to insulin stimulus GO:1900078
Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
1 Q9WTI7 (/ISO)
Positive regulation of vascular endothelial growth factor signaling pathway GO:1900748
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
1 O00159 (/IMP)
Positive regulation of vascular endothelial growth factor signaling pathway GO:1900748
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
1 Q9WTI7 (/ISO)
Regulation of bicellular tight junction assembly GO:2000810
Any process that modulates the frequency, rate or extent of tight junction assembly.
1 O00159 (/IMP)
Regulation of bicellular tight junction assembly GO:2000810
Any process that modulates the frequency, rate or extent of tight junction assembly.
1 Q9WTI7 (/ISO)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 F5H6E2 (/IDA) O00159 (/IDA) Q9WTI7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O00159 (/TAS) Q9WTI7 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
2 F5H6E2 (/IDA) O00159 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 O00159 (/IDA) Q63355 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q63355 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9WTI7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O00159 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O00159 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WTI7 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 F1Q147 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WTI7 (/ISO)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 O00159 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 Q9WTI7 (/ISO)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q9WTI7 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 O00159 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q9WTI7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O00159 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O00159 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9WTI7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9WTI7 (/TAS)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
1 O00159 (/IDA)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
1 Q9WTI7 (/ISO)
Unconventional myosin complex GO:0016461
A portmanteau term for myosins other than myosin II.
1 O00159 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9WTI7 (/ISO)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
1 Q9WTI7 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q63355 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q9WTI7 (/ISO)
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
1 O00159 (/IDA)
Filamentous actin GO:0031941
A two-stranded helical polymer of the protein actin.
1 Q9WTI7 (/ISO)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
1 Q9WTI7 (/IDA)
Stereocilium bundle GO:0032421
A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
1 Q63355 (/IDA)
Stereocilium bundle GO:0032421
A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
1 Q9WTI7 (/ISO)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q63355 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q9WTI7 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q9WTI7 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q9WTI7 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O00159 (/HDA)
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