The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Calcium-transporting ATPase, transmembrane domain
".
FunFam 4: Sodium/potassium-transporting ATPase subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 52 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
27 |
A0A060YJC3 (/IDA)
C0H8U1 (/IDA)
P05023 (/IDA)
P05024 (/IDA)
P06685 (/IDA)
P06686 (/IDA)
P06686 (/IDA)
P06686 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
(17 more) |
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
22 |
P04074 (/ISS)
P04074 (/ISS)
P05023 (/ISS)
P05024 (/ISS)
P06687 (/ISS)
P06687 (/ISS)
P13607 (/ISS)
P13607 (/ISS)
P18907 (/ISS)
P24797 (/ISS)
(12 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
21 |
A2VDL6 (/IPI)
F1MR06 (/IPI)
P05023 (/IPI)
P05024 (/IPI)
P06685 (/IPI)
P06686 (/IPI)
P06686 (/IPI)
P06686 (/IPI)
P06687 (/IPI)
P06687 (/IPI)
(11 more) |
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
18 |
P13607 (/IMP)
P13607 (/IMP)
P13637 (/IMP)
P13637 (/IMP)
P13637 (/IMP)
P13637 (/IMP)
P13637 (/IMP)
P13637 (/IMP)
P50993 (/IMP)
P50993 (/IMP)
(8 more) |
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
|
12 |
P05023 (/IPI)
P13637 (/IPI)
P13637 (/IPI)
P13637 (/IPI)
P13637 (/IPI)
P13637 (/IPI)
P13637 (/IPI)
P50993 (/IPI)
P50993 (/IPI)
P50993 (/IPI)
(2 more) |
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
|
9 | P05023 (/IDA) P06686 (/IDA) P06686 (/IDA) P06686 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) |
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
8 | P06687 (/IDA) P06687 (/IDA) P13637 (/IDA) P13637 (/IDA) P13637 (/IDA) P13637 (/IDA) P13637 (/IDA) P13637 (/IDA) |
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
8 | P06687 (/NAS) P06687 (/NAS) P13637 (/NAS) P13637 (/NAS) P13637 (/NAS) P13637 (/NAS) P13637 (/NAS) P13637 (/NAS) |
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
7 | Q6PIC6 (/ISO) Q6PIC6 (/ISO) Q6PIE5 (/ISO) Q6PIE5 (/ISO) Q6PIE5 (/ISO) Q8VDN2 (/ISO) Q9WV27 (/ISO) |
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
6 | P13637 (/TAS) P13637 (/TAS) P13637 (/TAS) P13637 (/TAS) P13637 (/TAS) P13637 (/TAS) |
Showing 1 to 10 of 52 entries
There are 171 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
17 |
P05023 (/IDA)
P05024 (/IDA)
P06685 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P50993 (/IDA)
(7 more) |
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
|
16 |
P05023 (/IDA)
P05024 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P50993 (/IDA)
P50993 (/IDA)
(6 more) |
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
15 |
P05023 (/IDA)
P05024 (/IDA)
P06685 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P50993 (/IDA)
(5 more) |
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
|
14 |
P05023 (/IDA)
P05024 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P50993 (/IDA)
P50993 (/IDA)
(4 more) |
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
13 |
P05023 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
(3 more) |
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
13 |
P05023 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
(3 more) |
Cell communication by electrical coupling involved in cardiac conduction GO:0086064
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.
|
12 |
P05023 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
(2 more) |
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
10 | P04074 (/ISS) P04074 (/ISS) P05023 (/ISS) P05024 (/ISS) P18907 (/ISS) P50997 (/ISS) Q08DA1 (/ISS) Q5RDR3 (/ISS) Q8VDN2 (/ISS) Q9N0Z6 (/ISS) |
Cellular response to steroid hormone stimulus GO:0071383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
|
9 | P05023 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) Q6PIE5 (/IDA) Q6PIE5 (/IDA) Q6PIE5 (/IDA) |
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
|
7 | A0A2R8Q7T9 (/IMP) A0A2R8Q8K8 (/IMP) B0S5Q5 (/IMP) Q7ZU25 (/IMP) Q90X34 (/IMP) Q9DGL5 (/IMP) Q9DGL6 (/IMP) |
Showing 1 to 10 of 171 entries
There are 81 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
30 |
P04074 (/ISS)
P04074 (/ISS)
P05023 (/ISS)
P05024 (/ISS)
P06685 (/ISS)
P09572 (/ISS)
P18907 (/ISS)
P25489 (/ISS)
P30714 (/ISS)
P50997 (/ISS)
(20 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
26 |
P04074 (/ISS)
P04074 (/ISS)
P05024 (/ISS)
P06687 (/ISS)
P06687 (/ISS)
P09572 (/ISS)
P18907 (/ISS)
P24797 (/ISS)
P24798 (/ISS)
P25489 (/ISS)
(16 more) |
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
22 |
P05023 (/IDA)
P05024 (/IDA)
P06685 (/IDA)
P06686 (/IDA)
P06686 (/IDA)
P06686 (/IDA)
P06687 (/IDA)
P06687 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
(12 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
16 |
P05023 (/IDA)
P06685 (/IDA)
P13607 (/IDA)
P13607 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
P13637 (/IDA)
(6 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
13 |
P05023 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P13637 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
P50993 (/TAS)
(3 more) |
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
13 |
P13607 (/IC)
P13607 (/IC)
P13637 (/IC)
P13637 (/IC)
P13637 (/IC)
P13637 (/IC)
P13637 (/IC)
P13637 (/IC)
P50993 (/IC)
P50993 (/IC)
(3 more) |
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
|
12 |
P05023 (/HDA)
P13637 (/HDA)
P13637 (/HDA)
P13637 (/HDA)
P13637 (/HDA)
P13637 (/HDA)
P13637 (/HDA)
P50993 (/HDA)
P50993 (/HDA)
P50993 (/HDA)
(2 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
10 | P06685 (/IDA) P06687 (/IDA) P06687 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P50993 (/IDA) P90735 (/IDA) Q8VDN2 (/IDA) |
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
10 | P06685 (/IDA) P06686 (/IDA) P06686 (/IDA) P06686 (/IDA) Q6PIC6 (/IDA) Q6PIC6 (/IDA) Q6PIE5 (/IDA) Q6PIE5 (/IDA) Q6PIE5 (/IDA) Q8VDN2 (/IDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
10 | P13637 (/ISS) P13637 (/ISS) P13637 (/ISS) P13637 (/ISS) P13637 (/ISS) P13637 (/ISS) P24798 (/ISS) P58312 (/ISS) Q6PIC6 (/ISS) Q6PIC6 (/ISS) |
Showing 1 to 10 of 81 entries