The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 99: D(2) dopamine receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 28 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
8 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P61168 (/IDA) P61169 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P61168 (/IPI) P61169 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
7 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P61169 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI) P14416 (/IPI)
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
4 F1QQR5 (/ISS) Q7T1A2 (/ISS) Q8AWE0 (/ISS) X1WBR1 (/ISS)
Organic cyclic compound binding GO:0097159
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
2 A0A077K956 (/IDA) A9YZQ5 (/IDA)
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
1 P61168 (/IMP)
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
1 P61168 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P61168 (/IDA)
Dopamine neurotransmitter receptor activity GO:0004952
Combining with the neurotransmitter dopamine to initiate a change in cell activity.
1 P61168 (/IDA)
Showing 1 to 10 of 28 entries

There are 220 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
8 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P61168 (/IDA) P61169 (/IDA)
Phospholipase C-activating dopamine receptor signaling pathway GO:0060158
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
7 P14416 (/IGI) P14416 (/IGI) P14416 (/IGI) P14416 (/IGI) P14416 (/IGI) P14416 (/IGI) P61168 (/IGI)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Nervous system process involved in regulation of systemic arterial blood pressure GO:0001976
The regulation of blood pressure mediated by detection of stimuli and a neurological response.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
6 P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS)
Neuron-neuron synaptic transmission GO:0007270
The process of synaptic transmission from a neuron to another neuron across a synapse.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Showing 1 to 10 of 220 entries

There are 51 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P61169 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS) P14416 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
6 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
6 P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS) P14416 (/ISS)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
6 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA)
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
6 P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA) P14416 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 F1QQR5 (/ISS) Q7T1A2 (/ISS) Q8AWE0 (/ISS) X1WBR1 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P61168 (/IDA) P61169 (/IDA)
Showing 1 to 10 of 51 entries
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