The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 75: orexin receptor type 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Orexin receptor activity GO:0016499
Combining with orexin to initiate a change in cell activity.
8 O43613 (/IDA) O43614 (/IDA) O43614 (/IDA) P56718 (/IDA) P56719 (/IDA) P58308 (/IDA) Q9TUP7 (/IDA) Q9TUP7 (/IDA)
Orexin receptor activity GO:0016499
Combining with orexin to initiate a change in cell activity.
7 O62809 (/ISS) O62809 (/ISS) O97661 (/ISS) P58307 (/ISS) Q0GBZ5 (/ISS) Q9TUP7 (/ISS) Q9TUP7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P58307 (/IPI) P58308 (/IPI)
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
2 O43614 (/TAS) O43614 (/TAS)
Orexin receptor activity GO:0016499
Combining with orexin to initiate a change in cell activity.
2 P58307 (/ISO) P58308 (/ISO)
Orexin receptor activity GO:0016499
Combining with orexin to initiate a change in cell activity.
2 P56718 (/TAS) P56719 (/TAS)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 P56718 (/IDA) P56719 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 P58307 (/ISO) P58308 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P56719 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P58308 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 O43613 (/TAS)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
10 O62809 (/ISS) O62809 (/ISS) O97661 (/ISS) P56718 (/ISS) P56719 (/ISS) P58307 (/ISS) P58308 (/ISS) Q0GBZ5 (/ISS) Q9TUP7 (/ISS) Q9TUP7 (/ISS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
8 O62809 (/ISS) O62809 (/ISS) O97661 (/ISS) P58307 (/ISS) P58308 (/ISS) Q0GBZ5 (/ISS) Q9TUP7 (/ISS) Q9TUP7 (/ISS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
7 O43613 (/IDA) O43614 (/IDA) O43614 (/IDA) P56718 (/IDA) P56719 (/IDA) Q9TUP7 (/IDA) Q9TUP7 (/IDA)
Regulation of circadian sleep/wake cycle, wakefulness GO:0010840
Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.
6 O43614 (/ISS) O43614 (/ISS) O62809 (/ISS) O62809 (/ISS) P56719 (/ISS) P58308 (/ISS)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
5 O43613 (/IDA) O43614 (/IDA) O43614 (/IDA) Q9TUP7 (/IDA) Q9TUP7 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P56718 (/IDA) P56719 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P58307 (/ISO) P58308 (/ISO)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
2 P58307 (/ISO) P58308 (/ISO)
Regulation of circadian sleep/wake cycle, wakefulness GO:0010840
Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.
2 Q9TUP7 (/IMP) Q9TUP7 (/IMP)
Melatonin metabolic process GO:0030186
The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine).
2 A1YQE3 (/IMP) A7KBS6 (/IMP)
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
2 A1YQE3 (/IMP) A7KBS6 (/IMP)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
2 A1YQE3 (/IMP) A7KBS6 (/IMP)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
2 P58307 (/ISO) P58308 (/ISO)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P58308 (/IDA)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P56719 (/IDA)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P58308 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P58307 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
18 A0A087R306 (/ISS) A0A091F041 (/ISS) A0A091GH07 (/ISS) A0A091I143 (/ISS) A0A091J828 (/ISS) A0A091VXT3 (/ISS) A0A091WMB4 (/ISS) A0A093IAN3 (/ISS) A0A093S790 (/ISS) A0A099ZJI8 (/ISS)
(8 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
18 A0A087R306 (/ISS) A0A091F041 (/ISS) A0A091GH07 (/ISS) A0A091I143 (/ISS) A0A091J828 (/ISS) A0A091VXT3 (/ISS) A0A091WMB4 (/ISS) A0A093IAN3 (/ISS) A0A093S790 (/ISS) A0A099ZJI8 (/ISS)
(8 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
10 O62809 (/ISS) O62809 (/ISS) O97661 (/ISS) P56718 (/ISS) P56719 (/ISS) P58307 (/ISS) P58308 (/ISS) Q0GBZ5 (/ISS) Q9TUP7 (/ISS) Q9TUP7 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 O43613 (/IDA) O43614 (/IDA) O43614 (/IDA) Q9TUP7 (/IDA) Q9TUP7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O43613 (/TAS) O43614 (/TAS) O43614 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P58307 (/ISO) P58308 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q5TMB6 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q5TMB6 (/IDA)
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