The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: Taste receptor type 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
7 Q9JKE7 (/TAS) Q9JKT2 (/TAS) Q9JKT3 (/TAS) Q9NYW4 (/TAS) Q9NYW4 (/TAS) Q9NYW5 (/TAS) Q9NYW7 (/TAS)
Bitter taste receptor activity GO:0033038
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
7 P59534 (/IDA) P59535 (/IDA) Q2AB83 (/IDA) Q9NYW4 (/IDA) Q9NYW4 (/IDA) Q9NYW5 (/IDA) Q9NYW7 (/IDA)
Bitter taste receptor activity GO:0033038
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
6 A0A090C7S0 (/IMP) G1NQR8 (/IMP) H0ZSM0 (/IMP) Q2AB81 (/IMP) Q2AB82 (/IMP) Q2AB83 (/IMP)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
5 Q7TQA5 (/NAS) Q7TQA6 (/NAS) Q7TQA9 (/NAS) Q7TQB8 (/NAS) Q7TQB9 (/NAS)
Bitter taste receptor activity GO:0033038
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
5 Q7TQA5 (/ISO) Q7TQA6 (/ISO) Q7TQB8 (/ISO) Q9JKT2 (/ISO) Q9JKT3 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q2AB83 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P59551 (/NAS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
8 P59534 (/TAS) P59535 (/TAS) P59536 (/TAS) P59551 (/TAS) Q9NYW4 (/TAS) Q9NYW4 (/TAS) Q9NYW5 (/TAS) Q9NYW7 (/TAS)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
7 P59534 (/IDA) P59535 (/IDA) Q67ES7 (/IDA) Q9NYW4 (/IDA) Q9NYW4 (/IDA) Q9NYW5 (/IDA) Q9NYW7 (/IDA)
Calcium ion import into cytosol GO:1902656
The directed movement of calcium ion into a cytosol.
6 A0A090C7S0 (/IMP) G1NQR8 (/IMP) H0ZSM0 (/IMP) Q2AB81 (/IMP) Q2AB82 (/IMP) Q2AB83 (/IMP)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
5 Q7TQA5 (/ISO) Q7TQA6 (/ISO) Q7TQB8 (/ISO) Q9JKT2 (/ISO) Q9JKT3 (/ISO)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
5 Q7TQA5 (/NAS) Q7TQA6 (/NAS) Q7TQA9 (/NAS) Q7TQB8 (/NAS) Q7TQB9 (/NAS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
5 G1NQR8 (/IDA) H0ZSM0 (/IDA) Q2AB81 (/IDA) Q2AB82 (/IDA) Q2AB83 (/IDA)
Cellular response to chloramphenicol GO:0072747
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus.
4 G1NQR8 (/IDA) Q2AB81 (/IDA) Q2AB82 (/IDA) Q2AB83 (/IDA)
Cellular response to diphenidol GO:1904561
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus.
4 G1NQR8 (/IDA) Q2AB81 (/IDA) Q2AB82 (/IDA) Q2AB83 (/IDA)
Response to phenylpropanoid GO:0080184
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin.
3 G1NQR8 (/IDA) Q2AB82 (/IDA) Q2AB83 (/IDA)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
2 Q9NYW4 (/TAS) Q9NYW4 (/TAS)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
2 G1NQR8 (/IDA) Q2AB82 (/IDA)
Cellular response to cycloheximide GO:0071409
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.
2 H0ZSM0 (/IDA) Q2AB81 (/IDA)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
1 Q9JKT3 (/ISA)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
1 P59532 (/TAS)
Respiratory gaseous exchange by respiratory system GO:0007585
The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
1 Q9JKT3 (/IMP)
Sensory perception of bitter taste GO:0050913
The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 P59551 (/NAS)
Cellular response to nicotine GO:0071316
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 Q2AB83 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q2AB81 (/IDA)
Cellular response to erythromycin GO:0072743
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus.
1 Q2AB81 (/IDA)
Cellular response to toxic substance GO:0097237
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q2AB83 (/IDA)
Cellular response to chloroquine GO:1902350
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus.
1 Q2AB83 (/IDA)
Response to dextromethorphan GO:1904558
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus.
1 Q2AB83 (/IDA)
Response to diphenidol GO:1904560
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus.
1 Q2AB83 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P59534 (/TAS) P59535 (/TAS) P59536 (/TAS) P59551 (/TAS) Q9NYW4 (/TAS) Q9NYW4 (/TAS) Q9NYW5 (/TAS) Q9NYW7 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 P59534 (/IC) P59535 (/IC) Q9NYW4 (/IC) Q9NYW4 (/IC) Q9NYW5 (/IC) Q9NYW7 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 Q7TQA5 (/NAS) Q7TQA6 (/NAS) Q7TQA9 (/NAS) Q7TQB8 (/NAS) Q7TQB9 (/NAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 A6H696 (/ISO) P59532 (/ISO) Q7M708 (/ISO) Q7TQA9 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P59536 (/IDA) P59551 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7TQA6 (/ISO)
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