The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 42: Taste receptor type 2 member 7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
17 Q9JKE8 (/TAS) Q9JKE9 (/TAS) Q9JKF0 (/TAS) Q9JKT4 (/TAS) Q9JKT4 (/TAS) Q9JKT5 (/TAS) Q9JKT6 (/TAS) Q9JKT7 (/TAS) Q9JKT8 (/TAS) Q9JKT9 (/TAS)
(7 more)
Bitter taste receptor activity GO:0033038
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
12 P59537 (/IDA) P59538 (/IDA) P59540 (/IDA) P59541 (/IDA) P59544 (/IDA) Q496D7 (/IDA) Q9NYV8 (/IDA) Q9NYV9 (/IDA) Q9NYW0 (/IDA) Q9NYW2 (/IDA)
(2 more)
Bitter taste receptor activity GO:0033038
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
5 P59530 (/ISO) Q7M720 (/ISO) Q7M722 (/ISO) Q7TQA4 (/ISO) Q7TQA7 (/ISO)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
2 P59537 (/IDA) Q9NYV8 (/IDA)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
2 Q7TQA4 (/NAS) Q7TQA7 (/NAS)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
1 Q7TQA4 (/ISO)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
16 P59537 (/TAS) P59538 (/TAS) P59539 (/TAS) P59540 (/TAS) P59541 (/TAS) P59542 (/TAS) P59543 (/TAS) P59544 (/TAS) Q7RTR8 (/TAS) Q9NYV8 (/TAS)
(6 more)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
12 P59537 (/IDA) P59538 (/IDA) P59540 (/IDA) P59541 (/IDA) P59544 (/IDA) Q496D7 (/IDA) Q9NYV8 (/IDA) Q9NYV9 (/IDA) Q9NYW0 (/IDA) Q9NYW2 (/IDA)
(2 more)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
5 P59530 (/ISO) Q7M720 (/ISO) Q7M722 (/ISO) Q7TQA4 (/ISO) Q7TQA7 (/ISO)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
5 P59528 (/TAS) P59530 (/TAS) Q7M712 (/TAS) Q7M717 (/TAS) Q7M725 (/TAS)
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
2 Q7TQA4 (/NAS) Q7TQA7 (/NAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P59537 (/IC) Q9NYV8 (/IC)
Sensory perception of bitter taste GO:0050913
The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
2 Q9JKT4 (/IMP) Q9JKT4 (/IMP)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q9NYV9 (/IMP)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q7M720 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 P59537 (/TAS) P59538 (/TAS) P59539 (/TAS) P59540 (/TAS) P59541 (/TAS) P59542 (/TAS) P59543 (/TAS) P59544 (/TAS) Q7RTR8 (/TAS) Q9NYV8 (/TAS)
(6 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 P59537 (/IC) P59538 (/IC) P59540 (/IC) P59541 (/IC) P59544 (/IC) Q496D7 (/IC) Q9NYV8 (/IC) Q9NYV9 (/IC) Q9NYW0 (/IC) Q9NYW2 (/IC)
(2 more)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
4 Q5Y500 (/ISS) Q645T3 (/ISS) Q646B4 (/ISS) Q646F8 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P59539 (/IDA) P59542 (/IDA) Q7RTR8 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q7TQA4 (/NAS) Q7TQA7 (/NAS)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 P59537 (/IDA)
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