The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: Muscarinic acetylcholine receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
8 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08173 (/TAS) P08173 (/TAS) P08173 (/TAS) P08485 (/TAS)
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
7 P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P10980 (/IDA) P32211 (/IDA) P32211 (/IDA)
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
7 P06199 (/ISS) P30372 (/ISS) P41985 (/ISS) P41985 (/ISS) Q9ERZ4 (/ISS) Q9N2A7 (/ISS) Q9N2A7 (/ISS)
Arrestin family protein binding GO:1990763
Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.
4 P08172 (/IPI) P08172 (/IPI) P08172 (/IPI) P08172 (/IPI)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2 P32211 (/ISO) P32211 (/ISO)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 P08485 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P08485 (/IPI)
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q9ERZ4 (/IMP)
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q9ERZ4 (/ISO)
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 P17200 (/NAS)
Showing 1 to 10 of 11 entries

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
7 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08173 (/TAS) P08173 (/TAS) P08173 (/TAS)
G protein-coupled acetylcholine receptor signaling pathway GO:0007213
Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
7 P06199 (/ISS) P30372 (/ISS) P41985 (/ISS) P41985 (/ISS) Q9ERZ4 (/ISS) Q9N2A7 (/ISS) Q9N2A7 (/ISS)
G protein-coupled acetylcholine receptor signaling pathway GO:0007213
Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
5 P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P10980 (/IDA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207
The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
4 P08172 (/IEP) P08172 (/IEP) P08172 (/IEP) P08172 (/IEP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Showing 1 to 10 of 23 entries

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 P06199 (/ISS) P10980 (/ISS) P30372 (/ISS) P41985 (/ISS) P41985 (/ISS) Q9ERZ4 (/ISS) Q9N2A7 (/ISS) Q9N2A7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08173 (/TAS) P08173 (/TAS) P08173 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
7 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08173 (/TAS) P08173 (/TAS) P08173 (/TAS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
7 G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA) P08485 (/IDA) P10980 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P10980 (/IDA)
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA) G7MML6 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P08172 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P08485 (/IDA) P10980 (/IDA) P32211 (/IDA) P32211 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P08172 (/IDA) P08172 (/IDA) P08172 (/IDA) P08172 (/IDA)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
4 P08172 (/TAS) P08172 (/TAS) P08172 (/TAS) P08172 (/TAS)
Showing 1 to 10 of 34 entries
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