The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 346: Adrenergic, alpha-2D-, receptor a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Alpha2-adrenergic receptor activity GO:0004938
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
|
2 | Q8JG69 (/IDA) Q8JG70 (/IDA) |
|
Alpha2-adrenergic receptor activity GO:0004938
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
|
2 | Q8JG69 (/ISS) Q8JG70 (/ISS) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of epinephrine secretion GO:0032811
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.
|
4 | A0A060X727 (/IMP) A0A060Y1K1 (/IMP) A0A060YPY0 (/IMP) A0A060YTQ8 (/IMP) |
|
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
4 | A0A060X727 (/IDA) A0A060Y1K1 (/IDA) A0A060YPY0 (/IDA) A0A060YTQ8 (/IDA) |
|
Adrenergic receptor signaling pathway GO:0071875
A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
|
4 | A0A060X727 (/IMP) A0A060Y1K1 (/IMP) A0A060YPY0 (/IMP) A0A060YTQ8 (/IMP) |
|
Adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0071881
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
2 | Q8JG69 (/IDA) Q8JG70 (/IDA) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q8JG69 (/IC) Q8JG70 (/IC) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q8JG69 (/ISS) Q8JG70 (/ISS) |
