The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 310: 5-hydroxytryptamine receptor 2B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Gi/o-coupled serotonin receptor activity GO:0001586
Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
|
2 | P28285 (/NAS) P28286 (/NAS) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
2 | P28285 (/IDA) P28286 (/IDA) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
2 | P28285 (/ISS) P28286 (/ISS) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
2 | P28285 (/TAS) P28286 (/TAS) |
|
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
2 | P28285 (/ISS) P28286 (/ISS) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
2 | P28285 (/IDA) P28286 (/IDA) |
|
Adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
2 | P28285 (/TAS) P28286 (/TAS) |
|
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
2 | P28285 (/IDA) P28286 (/IDA) |
|
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
2 | P28285 (/TAS) P28286 (/TAS) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
2 | P28285 (/IDA) P28286 (/IDA) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
2 | P28285 (/ISS) P28286 (/ISS) |
|
Inter-male aggressive behavior GO:0002121
Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
|
1 | P28285 (/IMP) |
|
Anesthesia-resistant memory GO:0007615
The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.
|
1 | P28285 (/IDA) |
|
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
|
1 | P28285 (/IMP) |
|
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
|
1 | P28286 (/IMP) |
|
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
|
1 | P28285 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P28285 (/ISS) P28286 (/ISS) |
