The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31: 5-hydroxytryptamine (Serotonin) receptor 2A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 26 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
9 O46635 (/IDA) P08909 (/IDA) P14842 (/IDA) P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA) Q02152 (/IDA) Q50DZ8 (/IDA)
Serotonin binding GO:0051378
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
9 O46635 (/IDA) P14842 (/IDA) P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P30994 (/IDA) P41595 (/IDA) Q02152 (/IDA) Q50DZ8 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
7 O46635 (/IDA) P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA) Q02152 (/IDA) Q50DZ8 (/IDA)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Gq/11-coupled serotonin receptor activity GO:0001587
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
4 P08909 (/ISS) P34968 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Serotonin binding GO:0051378
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
3 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
3 P28223 (/TAS) P28223 (/TAS) Q02152 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P08909 (/IPI) P14842 (/IPI) P30994 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
3 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS)
Serotonin binding GO:0051378
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
3 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS)
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886
Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.
3 P28223 (/IDA) P28223 (/IDA) P28335 (/IDA)
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886
Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.
3 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
2 P14842 (/IMP) P41595 (/IMP)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
2 P08909 (/IMP) P34968 (/IMP)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P35363 (/ISO) P35363 (/ISO)
Gq/11-coupled serotonin receptor activity GO:0001587
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
1 P28335 (/IDA)
Gq/11-coupled serotonin receptor activity GO:0001587
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
1 P34968 (/ISO)
Gq/11-coupled serotonin receptor activity GO:0001587
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
1 Q8UUG8 (/NAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q02152 (/IMP)
Neurotransmitter receptor activity GO:0030594
Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
1 Q8UUG8 (/NAS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P14842 (/IPI)

There are 189 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
7 O46635 (/IDA) P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA) Q02152 (/IDA) Q50DZ8 (/IDA)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Positive regulation of phosphatidylinositol biosynthetic process GO:0010513
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Intestine smooth muscle contraction GO:0014827
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Vasoconstriction GO:0042310
A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
5 O46635 (/IDA) P28223 (/IDA) P28223 (/IDA) P41595 (/IDA) Q50DZ8 (/IDA)
Positive regulation of cell division GO:0051781
Any process that activates or increases the frequency, rate or extent of cell division.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS) Q50DZ8 (/ISS)
Cellular response to temperature stimulus GO:0071502
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
5 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) P41595 (/ISS) Q50DZ8 (/ISS)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
4 P08909 (/ISS) P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
4 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q50DZ8 (/ISS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
4 P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
4 P28223 (/TAS) P28223 (/TAS) P28335 (/TAS) P41595 (/TAS)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
4 P28223 (/IMP) P28223 (/IMP) P28335 (/IMP) P41595 (/IMP)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Positive regulation of phosphatidylinositol biosynthetic process GO:0010513
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
4 P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA)
Positive regulation of phosphatidylinositol biosynthetic process GO:0010513
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Regulation of nervous system process GO:0031644
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
4 P08909 (/ISS) P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Regulation of appetite GO:0032098
Any process which modulates appetite, the desire or physical craving for food.
4 P08909 (/ISS) P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Regulation of corticotropin-releasing hormone secretion GO:0043397
Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.
4 P08909 (/ISS) P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
4 P28223 (/IMP) P28223 (/IMP) P28335 (/IMP) P41595 (/IMP)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
4 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q02152 (/ISS)
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
4 P08909 (/ISS) P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
4 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q50DZ8 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
4 P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P41595 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
4 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q50DZ8 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
3 P28223 (/IDA) P28223 (/IDA) P41595 (/IDA)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
3 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO)
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
3 P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 P28223 (/TAS) P28223 (/TAS) P28335 (/TAS)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
3 P28335 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
3 P28223 (/IDA) P28223 (/IDA) P41595 (/IDA)
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
3 P34968 (/IMP) P35363 (/IMP) P35363 (/IMP)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
3 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
2 P35363 (/ISO) P35363 (/ISO)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
2 P41595 (/IMP) Q02152 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P35363 (/ISO) P35363 (/ISO)
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 P08909 (/IDA) P14842 (/IDA)
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
2 P28223 (/TAS) P28223 (/TAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
2 P35363 (/ISO) P35363 (/ISO)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
2 P08909 (/IMP) P34968 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
2 P35363 (/ISO) P35363 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P14842 (/IMP) P41595 (/IMP)
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
2 P35363 (/ISO) P35363 (/ISO)
Artery smooth muscle contraction GO:0014824
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.
2 P35363 (/ISO) P35363 (/ISO)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
2 P35363 (/ISO) P35363 (/ISO)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 P35363 (/ISO) P35363 (/ISO)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
2 P28335 (/IDA) P41595 (/IDA)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
2 P34968 (/ISO) Q02152 (/ISO)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
2 P35363 (/ISO) P35363 (/ISO)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 P35363 (/IMP) P35363 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P08909 (/IMP) P14842 (/IMP)
Negative regulation of potassium ion transport GO:0043267
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P35363 (/ISO) P35363 (/ISO)
Protein localization to cytoskeleton GO:0044380
A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.
2 P35363 (/IDA) P35363 (/IDA)
Positive regulation of glycolytic process GO:0045821
Any process that activates or increases the frequency, rate or extent of glycolysis.
2 P35363 (/IMP) P35363 (/IMP)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
2 P08909 (/IMP) P14842 (/IMP)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
2 P35363 (/ISO) P35363 (/ISO)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P35363 (/IMP) P35363 (/IMP)
Regulation of behavior GO:0050795
Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
2 P41595 (/IMP) Q02152 (/IMP)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
2 P35363 (/ISO) P35363 (/ISO)
Detection of mechanical stimulus involved in sensory perception of pain GO:0050966
The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
2 P35363 (/ISO) P35363 (/ISO)
Negative regulation of synaptic transmission, glutamatergic GO:0051967
Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
2 P35363 (/ISO) P35363 (/ISO)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 P41595 (/IMP) Q02152 (/IMP)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
2 P35363 (/ISO) P35363 (/ISO)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 P14842 (/IMP)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
1 P34968 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 Q02152 (/IMP)
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
1 P41595 (/IDA)
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
1 Q02152 (/ISO)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q02152 (/ISO)
G protein-coupled receptor internalization GO:0002031
The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
1 Q02152 (/IDA)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q02152 (/IMP)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
1 Q02152 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P14842 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P41595 (/IMP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
1 P08909 (/TAS)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P28335 (/IDA)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P34968 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P14842 (/IMP)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
1 Q02152 (/IMP)
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P34968 (/IMP)
Phospholipase C-activating serotonin receptor signaling pathway GO:0007208
The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 Q02152 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q02152 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P14842 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P14842 (/IMP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P34968 (/ISO)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P28335 (/TAS)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 P14842 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P41595 (/IDA)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P41595 (/IMP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q02152 (/ISO)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 Q02152 (/IMP)
Positive regulation of gamma-aminobutyric acid secretion GO:0014054
Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
1 P08909 (/IMP)
Positive regulation of gamma-aminobutyric acid secretion GO:0014054
Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
1 P34968 (/ISO)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 P08909 (/IMP)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 P34968 (/ISO)
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
1 P14842 (/IMP)
Artery smooth muscle contraction GO:0014824
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.
1 P14842 (/IMP)
Intestine smooth muscle contraction GO:0014827
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.
1 P41595 (/IMP)
Intestine smooth muscle contraction GO:0014827
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.
1 Q02152 (/ISO)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
1 P14842 (/IMP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P41595 (/IMP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 Q02152 (/ISO)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 P14842 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 P41595 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q02152 (/ISO)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
1 P14842 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P08909 (/IEP)
Phospholipase D-activating G protein-coupled receptor signaling pathway GO:0031583
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).
1 P08909 (/IMP)
Phospholipase D-activating G protein-coupled receptor signaling pathway GO:0031583
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).
1 P34968 (/ISO)
Regulation of nervous system process GO:0031644
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
1 P34968 (/IMP)
Regulation of appetite GO:0032098
Any process which modulates appetite, the desire or physical craving for food.
1 P34968 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 P30994 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 Q02152 (/ISO)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
1 P08909 (/IMP)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
1 P34968 (/ISO)
Hepatic stellate cell activation GO:0035733
A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.
1 P30994 (/IEP)
Negative regulation of locomotion GO:0040013
Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
1 P08909 (/IMP)
Negative regulation of locomotion GO:0040013
Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
1 P34968 (/ISO)
Vasoconstriction GO:0042310
A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure.
1 P41595 (/IMP)
Vasoconstriction GO:0042310
A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure.
1 Q02152 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q02152 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P41595 (/IEP)
Negative regulation of potassium ion transport GO:0043267
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P14842 (/IMP)
Regulation of corticotropin-releasing hormone secretion GO:0043397
Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.
1 P34968 (/IMP)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 P41595 (/IDA)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 P14842 (/IMP)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
1 P30994 (/IEP)
Negative regulation of dopamine metabolic process GO:0045963
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 P08909 (/IMP)
Negative regulation of dopamine metabolic process GO:0045963
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 P34968 (/ISO)
Inositol phosphate-mediated signaling GO:0048016
Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
1 P08909 (/IDA)
Inositol phosphate-mediated signaling GO:0048016
Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
1 P34968 (/ISO)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
1 P14842 (/IDA)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q02152 (/IMP)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q8UUG8 (/TAS)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 Q02152 (/IMP)
Regulation of behavior GO:0050795
Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
1 Q02152 (/ISO)
Regulation of behavior GO:0050795
Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
1 P30994 (/ISS)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
1 P14842 (/IMP)
Detection of mechanical stimulus involved in sensory perception of pain GO:0050966
The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
1 P14842 (/IMP)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
1 P41595 (/IDA)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
1 Q02152 (/ISO)
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
1 P34968 (/IMP)
Positive regulation of cell division GO:0051781
Any process that activates or increases the frequency, rate or extent of cell division.
1 Q02152 (/IMP)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
1 P08909 (/IMP)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
1 P34968 (/ISO)
Negative regulation of synaptic transmission, glutamatergic GO:0051967
Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 P14842 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P41595 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q02152 (/ISO)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 Q02152 (/ISO)
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
1 G1NQ48 (/IMP)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
1 P41595 (/IMP)
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
1 Q02152 (/ISO)
Cellular response to amine stimulus GO:0071418
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 P30994 (/IDA)
Cellular response to amine stimulus GO:0071418
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 Q02152 (/ISO)
Cellular response to temperature stimulus GO:0071502
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
1 Q02152 (/IDA)
Cellular response to serotonin GO:1904015
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.
1 P30994 (/IDA)
Cellular response to serotonin GO:1904015
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.
1 Q02152 (/ISO)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
1 P14842 (/EXP)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
1 P14842 (/IDA)

There are 36 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O46635 (/IDA) P14842 (/IDA) P28223 (/IDA) P28223 (/IDA) P28335 (/IDA) P30994 (/IDA) P41595 (/IDA) Q02152 (/IDA) Q50DZ8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P14842 (/IDA) P30994 (/IDA) P41595 (/IDA) Q02152 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS) Q50DZ8 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P34968 (/ISO) P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P28223 (/TAS) P28223 (/TAS) P28335 (/TAS) P41595 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P08909 (/ISS) P34968 (/ISS) Q5IS66 (/ISS) Q60F97 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A3RL34 (/ISS) D2H6T9 (/ISS) P30994 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
3 P35363 (/ISO) P35363 (/ISO) Q02152 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P35363 (/ISO) P35363 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P28223 (/TAS) P28223 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P14842 (/IDA) P30994 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P14842 (/IDA) P30994 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P14842 (/IDA) P30994 (/IDA)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
2 P35363 (/ISO) P35363 (/ISO)
Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
2 P35363 (/ISO) P35363 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P35363 (/ISO) P35363 (/ISO)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P35363 (/ISO) P35363 (/ISO)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P35363 (/ISO) P35363 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P41595 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q02152 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P14842 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P28335 (/IMP)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P34968 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P08909 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P34968 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P08909 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P34968 (/ISO)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
1 P14842 (/IDA)
Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
1 P14842 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P14842 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P14842 (/IDA)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P14842 (/IDA)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P14842 (/IDA)
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