The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30: trace amine-associated receptor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
16 Q5QD04 (/RCA) Q5QD05 (/RCA) Q5QD06 (/RCA) Q5QD07 (/RCA) Q5QD08 (/RCA) Q5QD09 (/RCA) Q5QD09 (/RCA) Q5QD10 (/RCA) Q5QD11 (/RCA) Q5QD12 (/RCA)
(6 more)
Trace-amine receptor activity GO:0001594
Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
13 A0A2R8RWD4 (/IDA) B3DHM5 (/IDA) Q5QD08 (/IDA) Q5QD16 (/IDA) Q5QD16 (/IDA) Q5QNN0 (/IDA) Q5QNN3 (/IDA) Q5QNP8 (/IDA) Q5QNQ1 (/IDA) Q923Y7 (/IDA)
(3 more)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
7 O14804 (/TAS) Q969N4 (/TAS) Q96RI8 (/TAS) Q96RI9 (/TAS) Q96RJ0 (/TAS) Q9P1P4 (/TAS) Q9P1P5 (/TAS)
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
4 Q5QNP2 (/IDA) Q923Y7 (/IDA) Q923Y7 (/IDA) Q923Y8 (/IDA)
Trace-amine receptor activity GO:0001594
Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
3 Q5QD24 (/ISS) Q5QD24 (/ISS) Q9P1P4 (/ISS)
Trimethylamine receptor activity GO:1990081
Combining with the biogenic amine trimethylamine to initiate a change in cell activity.
3 O14804 (/IDA) Q5QD14 (/IDA) Q5QD14 (/IDA)
Trace-amine receptor activity GO:0001594
Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
2 Q5QD15 (/ISO) Q923Y8 (/ISO)
2-phenylethylamine receptor activity GO:1990080
Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity.
2 Q5QD15 (/IDA) Q5QNN8 (/IDA)
Trimethylamine receptor activity GO:1990081
Combining with the biogenic amine trimethylamine to initiate a change in cell activity.
2 Q5QD14 (/ISO) Q5QD14 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q96RJ0 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q923Y8 (/ISO)
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
1 Q5QNP9 (/IDA)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
1 Q5QNP2 (/IDA)
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
1 Q5QNP6 (/IDA)
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q5QD15 (/ISO)
Polyamine binding GO:0019808
Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups.
1 Q5QNP2 (/IDA)
Putrescine binding GO:0019810
Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
1 Q5QNP2 (/IDA)
2-phenylethylamine receptor activity GO:1990080
Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity.
1 Q5QD15 (/IMP)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
17 Q5QD04 (/RCA) Q5QD05 (/RCA) Q5QD06 (/RCA) Q5QD07 (/RCA) Q5QD08 (/RCA) Q5QD09 (/RCA) Q5QD09 (/RCA) Q5QD10 (/RCA) Q5QD11 (/RCA) Q5QD12 (/RCA)
(7 more)
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
7 Q5QD08 (/IDA) Q5QD14 (/IDA) Q5QD14 (/IDA) Q5QD15 (/IDA) Q5QD16 (/IDA) Q5QD16 (/IDA) Q5QNP2 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
6 O14804 (/TAS) Q969N4 (/TAS) Q96RI8 (/TAS) Q96RI9 (/TAS) Q96RJ0 (/TAS) Q9P1P5 (/TAS)
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
3 Q5QD24 (/ISS) Q5QD24 (/ISS) Q9P1P4 (/ISS)
Mating behavior GO:0007617
The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
2 Q5QD14 (/TAS) Q5QD14 (/TAS)
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
2 Q5QD14 (/TAS) Q5QD14 (/TAS)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
1 Q5QD15 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O14804 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q923Y8 (/IDA)
Adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 Q923Y8 (/ISO)
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 Q5QD15 (/IMP)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
1 Q5QD15 (/IMP)
Soluble molecule recognition GO:0009995
The recognition of soluble molecules in the environment.
1 Q5QNP2 (/IDA)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q923Y9 (/IDA)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q923Y8 (/ISO)
Detection of chemical stimulus involved in sensory perception of smell GO:0050911
The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.
1 Q5QNP2 (/IEP)
Response to odorant GO:1990834
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.
1 Q5QNP2 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
17 Q5QD04 (/RCA) Q5QD05 (/RCA) Q5QD06 (/RCA) Q5QD07 (/RCA) Q5QD08 (/RCA) Q5QD09 (/RCA) Q5QD09 (/RCA) Q5QD10 (/RCA) Q5QD11 (/RCA) Q5QD12 (/RCA)
(7 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 Q5QD14 (/ISS) Q5QD14 (/ISS) Q5QD23 (/ISS) Q5QD23 (/ISS) Q5QD28 (/ISS) Q5QD28 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q5QD14 (/ISO) Q5QD14 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q96RJ0 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O14804 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O14804 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q923Y8 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5QNP2 (/IDA)
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