The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 296: C5a anaphylatoxin chemotactic receptor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | Q695P6 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9P296 (/IPI) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
Negative regulation of neutrophil chemotaxis GO:0090024
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
Regulation of interleukin-8 secretion GO:2000482
Any process that modulates the frequency, rate or extent of interleukin-8 secretion.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q695P6 (/TAS) |
|
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
|
1 | Q9P296 (/TAS) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q9P296 (/IMP) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q8BW93 (/ISO) |
|
Negative regulation of neutrophil chemotaxis GO:0090024
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | Q9P296 (/IMP) |
|
Negative regulation of neutrophil chemotaxis GO:0090024
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | Q8BW93 (/ISO) |
|
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
|
1 | Q9P296 (/IMP) |
|
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
|
1 | Q8BW93 (/ISO) |
|
Regulation of interleukin-8 secretion GO:2000482
Any process that modulates the frequency, rate or extent of interleukin-8 secretion.
|
1 | Q9P296 (/IMP) |
|
Regulation of interleukin-8 secretion GO:2000482
Any process that modulates the frequency, rate or extent of interleukin-8 secretion.
|
1 | Q8BW93 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
2 | Q695P6 (/ISS) Q8BW93 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9P296 (/TAS) |
|
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q9P296 (/IDA) |
|
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q8BW93 (/ISO) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q695P6 (/TAS) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
1 | Q9P296 (/IDA) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
1 | Q8BW93 (/ISO) |
