The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 295: B1 bradykinin receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bradykinin receptor activity GO:0004947
Combining with bradykinin to initiate a change in cell activity.
2 Q61125 (/ISO) Q61125 (/ISO)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
2 Q61125 (/IDA) Q61125 (/IDA)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
2 Q61125 (/ISO) Q61125 (/ISO)
Bradykinin receptor activity GO:0004947
Combining with bradykinin to initiate a change in cell activity.
1 P97583 (/IDA)
Bradykinin receptor activity GO:0004947
Combining with bradykinin to initiate a change in cell activity.
1 P46663 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P46663 (/IPI)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
1 P97583 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
2 Q61125 (/ISO) Q61125 (/ISO)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
2 Q61125 (/ISO) Q61125 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q61125 (/ISO) Q61125 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P46663 (/TAS) P97583 (/TAS)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
2 Q61125 (/ISO) Q61125 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q61125 (/ISO) Q61125 (/ISO)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 Q61125 (/ISO) Q61125 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 Q61125 (/ISO) Q61125 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 Q61125 (/IDA) Q61125 (/IDA)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
2 Q61125 (/ISO) Q61125 (/ISO)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
2 Q61125 (/ISO) Q61125 (/ISO)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P97583 (/IMP)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 P97583 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P97583 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P46663 (/TAS)
Protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
1 P97583 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P97583 (/IMP)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 P97583 (/IMP)
Cyclooxygenase pathway GO:0019371
The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
1 Q8HZN9 (/IMP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P97583 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P97583 (/IEP)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
1 P97583 (/IMP)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
1 P97583 (/IDA)
Smooth muscle relaxation of the bladder outlet GO:0060085
A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body.
1 Q8HZN9 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q61125 (/ISO) Q61125 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q61125 (/ISO) Q61125 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q61125 (/ISO) Q61125 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P46663 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P97583 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P46663 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P46663 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P97583 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P97583 (/IDA)
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