The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 258: G-protein coupled receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
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8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
8 | Q8MR64 (/ISS) Q8T0P6 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) |
Ecdysone binding GO:0035100
Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting.
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8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
8 | Q8MR64 (/ISS) Q8T0P6 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) |
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
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8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
|
8 | Q8MR64 (/IMP) Q8T0P6 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
|
8 | Q8MR64 (/IMP) Q8T0P6 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
Response to ecdysone GO:0035075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
|
8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
|
8 | Q8MR64 (/IMP) Q8T0P6 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
8 | Q8MR64 (/IMP) Q8T0P6 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
Habituation GO:0046959
A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
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8 | Q8MR64 (/IMP) Q8T0P6 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
Cellular response to sucrose stimulus GO:0071329
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
|
8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
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6 | Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) Q9VZD1 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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8 | Q8MR64 (/IDA) Q8T0P6 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) Q9VZD1 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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8 | Q8MR64 (/ISS) Q8T0P6 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) Q9VZD1 (/ISS) |