The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 209: p2Y purinoceptor 6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
UDP-activated nucleotide receptor activity GO:0045029
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.
4 Q15077 (/IDA) Q15077 (/IDA) Q9ERK9 (/IDA) Q9ERK9 (/IDA)
ADP receptor activity GO:0001621
Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 Q15077 (/IDA) Q15077 (/IDA)
ADP receptor activity GO:0001621
Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2 Q15077 (/TAS) Q15077 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q15077 (/IPI) Q15077 (/IPI)
Pyrimidine nucleotide binding GO:0019103
Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate.
2 Q9ERK9 (/IC) Q9ERK9 (/IC)
UDP-activated nucleotide receptor activity GO:0045029
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
UTP-activated nucleotide receptor activity GO:0045030
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.
2 Q15077 (/IDA) Q15077 (/IDA)
UTP-activated nucleotide receptor activity GO:0045030
Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q15077 (/ISS) Q15077 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q15077 (/TAS) Q15077 (/TAS)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 Q15077 (/IC) Q15077 (/IC)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 Q15077 (/TAS) Q15077 (/TAS)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
2 Q15077 (/TAS) Q15077 (/TAS)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Transepithelial chloride transport GO:0030321
The directed movement of chloride ions from one side of an epithelium to the other.
2 Q9ERK9 (/IDA) Q9ERK9 (/IDA)
Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031587
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031587
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
2 Q15077 (/ISS) Q15077 (/ISS)
Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031587
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
2 Q15077 (/TAS) Q15077 (/TAS)
Positive regulation of inositol trisphosphate biosynthetic process GO:0032962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
2 Q15077 (/IDA) Q15077 (/IDA)
Positive regulation of inositol trisphosphate biosynthetic process GO:0032962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Positive regulation of inositol trisphosphate biosynthetic process GO:0032962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
2 Q15077 (/TAS) Q15077 (/TAS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q15077 (/IDA) Q15077 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
2 Q9ERK9 (/IDA) Q9ERK9 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
2 Q9ERK9 (/IDA) Q9ERK9 (/IDA)
Cellular response to purine-containing compound GO:0071415
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.
2 Q15077 (/IDA) Q15077 (/IDA)
Cellular response to purine-containing compound GO:0071415
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
2 Q15077 (/IMP) Q15077 (/IMP)
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Cellular response to pyrimidine ribonucleotide GO:1905835
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus.
2 Q15077 (/IDA) Q15077 (/IDA)
Cellular response to pyrimidine ribonucleotide GO:1905835
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Cellular response to pyrimidine ribonucleotide GO:1905835
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus.
2 Q15077 (/ISS) Q15077 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q63371 (/IMP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 Q63371 (/IMP)
Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031587
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
1 Q63371 (/IMP)
Cellular response to pyrimidine ribonucleotide GO:1905835
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus.
1 Q63371 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q15077 (/IC) Q15077 (/IC)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q15077 (/TAS) Q15077 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q15077 (/TAS) Q15077 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9ERK9 (/ISO) Q9ERK9 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q63371 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q63371 (/IDA)
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