The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 208: Alpha-1D adrenergic receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P25100 (/IPI) P25100 (/IPI) P25100 (/IPI) |
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
|
2 | P23944 (/IDA) P97714 (/IDA) |
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
|
1 | P97714 (/ISO) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Neuron-glial cell signaling GO:0150099
Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.
|
3 | P25100 (/ISS) P25100 (/ISS) P25100 (/ISS) |
Negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure GO:0001986
Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.
|
1 | P97714 (/IMP) |
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994
A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.
|
1 | P97714 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P23944 (/IDA) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P97714 (/ISO) |
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
|
1 | P23944 (/IMP) |
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
|
1 | P97714 (/ISO) |
Micturition GO:0060073
The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.
|
1 | P23944 (/IMP) |
Micturition GO:0060073
The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.
|
1 | P97714 (/ISO) |
Neuron-glial cell signaling GO:0150099
Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.
|
1 | P97714 (/IGI) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P25100 (/TAS) P25100 (/TAS) P25100 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P23944 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P97714 (/ISO) |