The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 183: Urotensin-2 receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Urotensin II receptor activity GO:0001604
Combining with urotensin II to initiate a change in cell activity.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Urotensin II receptor activity GO:0001604
Combining with urotensin II to initiate a change in cell activity.
1 P49684 (/IDA)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
1 Q9UKP6 (/TAS)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of glomerular filtration GO:0003105
Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of circadian sleep/wake cycle, wakefulness GO:0010841
Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Negative regulation of renal sodium excretion GO:0035814
Any process that decreases the amount of sodium excreted in urine over a unit of time.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of circadian sleep/wake cycle, REM sleep GO:0046005
Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Negative regulation of glomerular filtration GO:0003105
Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
1 P49684 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9UKP6 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q9UKP6 (/TAS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P49684 (/IMP)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
1 Q9UKP6 (/TAS)
Positive regulation of circadian sleep/wake cycle, wakefulness GO:0010841
Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.
1 P49684 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 P49684 (/IMP)
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
1 P49684 (/IMP)
Negative regulation of renal sodium excretion GO:0035814
Any process that decreases the amount of sodium excreted in urine over a unit of time.
1 P49684 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P49684 (/IEP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P49684 (/IMP)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
1 P49684 (/IMP)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 P49684 (/IMP)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
1 P49684 (/IMP)
Positive regulation of circadian sleep/wake cycle, REM sleep GO:0046005
Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.
1 P49684 (/IMP)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 P49684 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 Q8VIH9 (/ISO) Q8VIH9 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 P49684 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P49684 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9UKP6 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9UKP6 (/TAS)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 P49684 (/IDA)
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