The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 174: beta-3 adrenergic receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Beta-adrenergic receptor activity GO:0004939
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Beta3-adrenergic receptor activity GO:0015052
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Beta-adrenergic receptor activity GO:0004939
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
|
2 | P13945 (/IDA) P13945 (/IDA) |
Beta-adrenergic receptor activity GO:0004939
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
|
2 | P25962 (/ISO) P25962 (/ISO) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P13945 (/IPI) P13945 (/IPI) |
Beta3-adrenergic receptor activity GO:0015052
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.
|
2 | P13945 (/IMP) P13945 (/IMP) |
Beta3-adrenergic receptor activity GO:0015052
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.
|
2 | P25962 (/ISO) P25962 (/ISO) |
Beta-3 adrenergic receptor binding GO:0031699
Interacting selectively and non-covalently with a beta-3 adrenergic receptor.
|
2 | P25962 (/IDA) P25962 (/IDA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P13945 (/IDA) P13945 (/IDA) |
Showing 1 to 10 of 15 entries
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Activation of adenylate cyclase activity GO:0007190
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
|
3 | P25962 (/IDA) P25962 (/IDA) P26255 (/IDA) |
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
3 | P13945 (/ISS) P13945 (/ISS) P26255 (/ISS) |
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
|
2 | P25962 (/IGI) P25962 (/IGI) |
Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025
A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.
|
2 | P25962 (/IDA) P25962 (/IDA) |
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
|
2 | P13945 (/TAS) P13945 (/TAS) |
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
|
2 | P13945 (/TAS) P13945 (/TAS) |
Energy reserve metabolic process GO:0006112
The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
|
2 | P13945 (/TAS) P13945 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | P13945 (/TAS) P13945 (/TAS) |
Showing 1 to 10 of 28 entries
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
17 |
O02662 (/ISS)
P25962 (/ISS)
P25962 (/ISS)
P26255 (/ISS)
P46626 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q28524 (/ISS)
Q60483 (/ISS)
Q8HZF7 (/ISS)
(7 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P25962 (/ISO) P25962 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P13945 (/TAS) P13945 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P13945 (/TAS) P13945 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P25962 (/IDA) P25962 (/IDA) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P13945 (/IDA) P13945 (/IDA) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P25962 (/ISO) P25962 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P26255 (/IDA) |
Showing 1 to 8 of 8 entries