The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 159: C-X-C chemokine receptor type 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
C-X-C chemokine binding GO:0019958
Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Chemokine binding GO:0019956
Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
4 | P49682 (/IPI) P49682 (/IPI) P49682 (/IPI) P49682 (/IPI) |
|
C-X-C chemokine receptor activity GO:0016494
Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
1 | Q9JII9 (/IPI) |
|
C-X-C chemokine receptor activity GO:0016494
Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
1 | O88410 (/ISO) |
|
Chemokine binding GO:0019956
Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
1 | O88410 (/ISO) |
|
C-X-C chemokine binding GO:0019958
Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
1 | O88410 (/ISO) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | O88410 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Chemokine (C-C motif) ligand 11 production GO:0071954
The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
|
5 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) Q9JII9 (/ISS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
4 | P49682 (/IDA) P49682 (/IDA) P49682 (/IDA) P49682 (/IDA) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
4 | P49682 (/IDA) P49682 (/IDA) P49682 (/IDA) P49682 (/IDA) |
|
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
|
1 | O88410 (/ISO) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | O88410 (/ISO) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | O88410 (/ISO) |
|
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
|
1 | O88410 (/ISO) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q9JII9 (/IDA) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | O88410 (/ISO) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | O88410 (/ISO) |
|
T cell chemotaxis GO:0010818
The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
|
1 | Q9JII9 (/IMP) |
|
T cell chemotaxis GO:0010818
The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
|
1 | O88410 (/ISO) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
1 | O88410 (/ISO) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
1 | Q9JII9 (/IDA) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
1 | O88410 (/ISO) |
|
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
1 | O88410 (/ISO) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | O88410 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O88410 (/ISO) |
|
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
|
1 | O88410 (/ISO) |
|
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
1 | O88410 (/ISO) |
|
Chemokine (C-C motif) ligand 11 production GO:0071954
The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | O88410 (/ISO) |
|
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
|
1 | O88410 (/ISO) |
|
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
|
1 | O88410 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O88410 (/ISS) Q5KSK8 (/ISS) Q5MD61 (/ISS) Q867B2 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) P49682 (/TAS) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | O88410 (/IDA) Q9JII9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9JII9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O88410 (/ISO) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | O88410 (/ISO) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | O88410 (/IDA) |
