The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 1511: Growth hormone secretagogue receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Growth hormone secretagogue receptor activity GO:0001616
Combining with ghrelin to initiate a change in cell activity.
|
1 | Q2F2Y0 (/ISS) |
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | Q2F2Y0 (/ISS) |
Growth hormone-releasing hormone receptor activity GO:0016520
Combining with growth hormone-releasing hormone to initiate a change in cell activity.
|
1 | Q2F2Y0 (/ISS) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q2F2Y0 (/ISS) |
Actin polymerization or depolymerization GO:0008154
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
|
1 | Q2F2Y0 (/ISS) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | Q2F2Y0 (/ISS) |
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
|
1 | Q2F2Y0 (/ISS) |
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
|
1 | Q2F2Y0 (/ISS) |
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | Q2F2Y0 (/ISS) |
Negative regulation of tumor necrosis factor biosynthetic process GO:0042536
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
1 | Q2F2Y0 (/ISS) |
Negative regulation of interleukin-6 biosynthetic process GO:0045409
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
|
1 | Q2F2Y0 (/ISS) |
Decidualization GO:0046697
The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
|
1 | Q2F2Y0 (/ISS) |
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | Q2F2Y0 (/ISS) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q2F2Y0 (/ISS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q2F2Y0 (/ISS) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q2F2Y0 (/ISS) |