The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 138: histamine H3 receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
4 | A0A1L1QZB1 (/IDA) Q195J1 (/IDA) Q6ZM33 (/IDA) Q9QYN8 (/IDA) |
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
1 | Q9Y5N1 (/TAS) |
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
1 | Q9QYN8 (/IDA) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of adenylate cyclase activity GO:0007194
Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
2 | P58406 (/ISO) P58406 (/ISO) |
Negative regulation of glutamate secretion GO:0014050
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Negative regulation of gamma-aminobutyric acid secretion GO:0014053
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Regulation of norepinephrine secretion GO:0014061
Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Negative regulation of serotonin secretion GO:0014063
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Drinking behavior GO:0042756
The specific behavior of an organism relating to the intake of liquids, especially water.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
|
2 | P58406 (/ISO) P58406 (/ISO) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q9Y5N1 (/TAS) |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
|
1 | Q9Y5N1 (/TAS) |
Negative regulation of adenylate cyclase activity GO:0007194
Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
|
1 | Q9QYN8 (/IDA) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q9QYN8 (/IMP) |
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
|
1 | Q9Y5N1 (/TAS) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | Q9QYN8 (/IEP) |
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
1 | Q9QYN8 (/IMP) |
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
1 | Q9QYN8 (/IMP) |
Negative regulation of glutamate secretion GO:0014050
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.
|
1 | Q9QYN8 (/IMP) |
Negative regulation of gamma-aminobutyric acid secretion GO:0014053
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
|
1 | Q9QYN8 (/IMP) |
Regulation of norepinephrine secretion GO:0014061
Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.
|
1 | Q9QYN8 (/IMP) |
Negative regulation of serotonin secretion GO:0014063
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
|
1 | Q9QYN8 (/IMP) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | Q9QYN8 (/IMP) |
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
|
1 | Q9QYN8 (/IMP) |
Drinking behavior GO:0042756
The specific behavior of an organism relating to the intake of liquids, especially water.
|
1 | Q9QYN8 (/IMP) |
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
|
1 | Q9QYN8 (/IMP) |
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
1 | Q9QYN8 (/IMP) |
Cognition GO:0050890
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
|
1 | Q9QYN8 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
|
2 | P58406 (/ISO) P58406 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9QYN8 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9Y5N1 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9Y5N1 (/TAS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q9QYN8 (/IDA) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
|
1 | Q9QYN8 (/IDA) |