The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 115: Melanin-concentrating hormone receptor 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8JZL2 (/IPI) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | P97639 (/IDA) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q8JZL2 (/ISO) |
Melanin-concentrating hormone receptor activity GO:0030273
Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.
|
1 | P97639 (/IDA) |
Melanin-concentrating hormone receptor activity GO:0030273
Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.
|
1 | Q8JZL2 (/ISO) |
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
1 | P97639 (/IDA) |
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
1 | Q8JZL2 (/ISO) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Feeding behavior GO:0007631
Behavior associated with the intake of food.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | P97639 (/IMP) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8JZL2 (/ISO) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | P97639 (/IMP) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q8JZL2 (/ISO) |
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P97639 (/IMP) |
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q8JZL2 (/ISO) |
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
|
1 | Q8JZL2 (/TAS) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P97639 (/IDA) Q8JZL2 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q99705 (/TAS) Q99705 (/TAS) |
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
2 | Q99705 (/IDA) Q99705 (/IDA) |
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
|
2 | Q99705 (/ISS) Q99705 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8JZL2 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P97639 (/ISS) |
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
1 | Q8JZL2 (/ISO) |
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
|
1 | Q8JZL2 (/IDA) |
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
|
1 | Q8JZL2 (/IDA) |