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CATH Superfamily 1.20.1050.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Glutathione S-transferase omega-1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutathione transferase. [EC: 2.5.1.18]
RX + glutathione = HX + R-S-glutathione.
  • A group of enzymes of broad specificity.
  • R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
  • Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
  • Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
 22 A0A481BZ29 A0A481BZ29 A8XT16 B6DYQ5 B6DYQ5 B6DYQ6 B6DYQ6 O09131 P34277 P34345
(12 more...)
Glutathione dehydrogenase (ascorbate). [EC: 1.8.5.1]
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
    		 22 A0A481BZ29 A0A481BZ29 A8XT16 B6DYQ5 B6DYQ5 B6DYQ6 B6DYQ6 O09131 P34277 P34345
    (12 more...)
    Methylarsonate reductase. [EC: 1.20.4.2]
    Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
    • The product, methylarsonite, is biologically methylated by EC 2.1.1.137 to form cacodylic acid.
    • Formerly EC 1.97.1.7.
    		 22 A0A481BZ29 A0A481BZ29 A8XT16 B6DYQ5 B6DYQ5 B6DYQ6 B6DYQ6 O09131 P34277 P34345
    (12 more...)
    Pyrimidodiazepine synthase. [EC: 1.5.4.1]
    2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one + glutathione disulfide + H(2)O = 6-pyruvoyltetrahydropterin + 2 glutathione.
    • In the reverse direction of reaction, the reduction of 6-pyruvoyl- tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring.
    • The pyrimidodiazepine involved is an acetyldihydro derivative.
    • Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
    		 1 Q9VSL3
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