CATH Superfamily 1.10.840.10
Ras guanine-nucleotide exchange factors catalytic domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Ras guanine-nucleotide exchange factors catalytic domain
".
FunFam 8: Ras-GEF domain-containing family member 1B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
11 |
A0JM95 (/ISS)
A0JM95 (/ISS)
A4IFE4 (/ISS)
A4IFE4 (/ISS)
Q28EC1 (/ISS)
Q28EC1 (/ISS)
Q5RC04 (/ISS)
Q5RC04 (/ISS)
Q6DBW1 (/ISS)
Q6DHR3 (/ISS)
(1 more) |
|
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
5 | Q0VAM2 (/IDA) Q0VAM2 (/IDA) Q0VAM2 (/IDA) Q0VAM2 (/IDA) Q8N9B8 (/IDA) |
|
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
5 | A0A0N4SVF2 (/ISO) A0A0N4SVR5 (/ISO) A6H650 (/ISO) B7ZNG9 (/ISO) Q8JZL7 (/ISO) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
4 | A0A0N4SVF2 (/ISO) A0A0N4SVR5 (/ISO) A6H650 (/ISO) B7ZNG9 (/ISO) |
|
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
4 | A0A0N4SVF2 (/ISO) A0A0N4SVR5 (/ISO) A6H650 (/ISO) B7ZNG9 (/ISO) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
2 | A0JM95 (/ISS) A0JM95 (/ISS) |
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | Q8N9B8 (/TAS) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q8N9B8 (/IDA) |
|
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
1 | Q8N9B8 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8N9B8 (/TAS) |
