CATH Superfamily 1.10.840.10
Ras guanine-nucleotide exchange factors catalytic domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Ras guanine-nucleotide exchange factors catalytic domain
".
FunFam 3: Ras guanyl-releasing protein 3 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 32 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
4 | O95267 (/TAS) O95267 (/TAS) Q7LDG7 (/TAS) Q8IV61 (/TAS) |
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
4 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) Q8TDF6 (/IDA) |
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
3 | Q1LZ97 (/ISS) Q8BTM9 (/ISS) Q8R5I4 (/ISS) |
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
3 | Q2PHE9 (/ISO) Q69ZX7 (/ISO) Q6NZH9 (/ISO) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | O95267 (/TAS) O95267 (/TAS) Q7LDG7 (/TAS) |
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
|
3 | O95267 (/TAS) O95267 (/TAS) Q7LDG7 (/TAS) |
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
3 | Q2PHE9 (/IPI) Q69ZX7 (/IPI) Q6NZH9 (/IPI) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
3 | Q2PHE9 (/IPI) Q69ZX7 (/IPI) Q6NZH9 (/IPI) |
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
|
2 | O95267 (/IMP) O95267 (/IMP) |
Showing 1 to 10 of 32 entries
There are 63 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
4 | O95267 (/TAS) O95267 (/TAS) Q8IV61 (/TAS) Q8TDF6 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
3 | O95267 (/TAS) O95267 (/TAS) Q7LDG7 (/TAS) |
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
3 | Q1LZ97 (/ISS) Q8BTM9 (/ISS) Q8R5I4 (/ISS) |
Response to extracellular stimulus GO:0009991
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
|
3 | Q1LZ97 (/ISS) Q8BTM9 (/ISS) Q8R5I4 (/ISS) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
3 | Q1LZ97 (/ISS) Q8BTM9 (/ISS) Q8R5I4 (/ISS) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
3 | O95267 (/IMP) O95267 (/IMP) Q9Z1S3 (/IMP) |
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
2 | O95267 (/IDA) O95267 (/IDA) |
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
2 | O95267 (/IMP) O95267 (/IMP) |
Showing 1 to 10 of 63 entries
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | F5H514 (/IDA) F5H514 (/IDA) H0YKM0 (/IDA) H0YMF3 (/IDA) O95267 (/IDA) O95267 (/IDA) Q7LDG7 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | O95267 (/TAS) O95267 (/TAS) Q2PHE9 (/TAS) Q7LDG7 (/TAS) Q8TDF6 (/TAS) Q9QUG9 (/TAS) Q9Z1S3 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | F5H514 (/IDA) F5H514 (/IDA) H0YKM0 (/IDA) H0YMF3 (/IDA) O95267 (/IDA) O95267 (/IDA) Q7LDG7 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | O95267 (/TAS) O95267 (/TAS) Q2PHE9 (/TAS) Q8IV61 (/TAS) Q8TDF6 (/TAS) Q9Z1S3 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Guanyl-nucleotide exchange factor complex GO:0032045
A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | Q2PHE9 (/IDA) Q69ZX7 (/IDA) Q6NZH9 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
2 | O95267 (/IDA) O95267 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9QUG9 (/ISO) Q9Z1S3 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9QUG9 (/ISO) Q9Z1S3 (/ISO) |
Showing 1 to 10 of 17 entries