The filoviridae are a group of viruses that cause haemorrhagic fevers with a high mortality rate. The family currently contains three viruses: Ebola virus sp., Lake Victoria marburgvirus and Reston ebolavirus, named after their corresponding outbreak regions.

This entry includes the Ebola VP35 protein, which acts as a component of the viral RNA polymerase complex, a viral assembly factor, and an inhibitor of host interferon (IFN) production. This superfamily represents the C-terminal helical subdomain of the inhibitory domain located at the C-terminus of VP35.

VP35 contains an N-terminal coiled-coil domain required for its oligomerisation and a C-terminal dsRNA-binding region (inhibitory domain, IID). The C-terminus mediates the dsRNA binding activity, which is critical for viral suppression of innate immunity and for virulence PMID:19122151.

The VP35 IID structure is organised into 2 subdomains: an N-terminal alpha-helical subdomain and a C-terminal beta-sheet subdomain. The helical subdomain (residues 221-283) is a 4-helical bundle PMID:19122151.

PFAM:PF02097,INTERPRO:IPR002953