The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Region D6 of dynein motor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Cytoplasmic dynein heavy chain 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 25 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
8 Q19542 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P34036 (/IPI) P38650 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q9JHU4 (/IPI) Q9SMH5 (/IPI)
Dynein light intermediate chain binding GO:0051959
Interacting selectively and non-covalently with a light intermediate chain of the dynein complex.
4 Q14204 (/IPI) Q14204 (/IPI) Q14204 (/IPI) Q9JHU4 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 Q14204 (/HDA) Q14204 (/HDA) Q14204 (/HDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 P34036 (/IDA) P45444 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
2 P34036 (/IDA) P45444 (/IDA)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
2 P34036 (/IDA) P37276 (/IDA)
Dynein light intermediate chain binding GO:0051959
Interacting selectively and non-covalently with a light intermediate chain of the dynein complex.
2 P37276 (/ISS) Q19542 (/ISS)
Motor activity GO:0003774
Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.
1 Q9SMH5 (/TAS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 P37276 (/IDA)
Showing 1 to 10 of 25 entries

There are 114 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
7 Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
6 F1LRT9 (/ISS) M0R9X8 (/ISS) P38650 (/ISS) Q14204 (/ISS) Q14204 (/ISS) Q14204 (/ISS)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
4 P45444 (/IMP) Q2U6C3 (/IMP) Q2U6C3 (/IMP) Q2U6C3 (/IMP)
Establishment of spindle localization GO:0051293
The directed movement of the spindle to a specific location in the cell.
4 Q14204 (/IMP) Q14204 (/IMP) Q14204 (/IMP) Q19020 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Sporocarp development involved in asexual reproduction GO:0000905
The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction.
3 Q2U6C3 (/IMP) Q2U6C3 (/IMP) Q2U6C3 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
3 Q2U6C3 (/IMP) Q2U6C3 (/IMP) Q2U6C3 (/IMP)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
3 Q14204 (/NAS) Q14204 (/NAS) Q14204 (/NAS)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
3 D6XEZ2 (/TAS) Q386R7 (/TAS) Q57UR9 (/TAS)
Showing 1 to 10 of 114 entries

There are 51 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
7 Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS) Q8IBG1 (/ISS)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
6 P34036 (/IDA) P45444 (/IDA) Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA) Q9SMH5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P34036 (/IDA) P37276 (/IDA) P38650 (/IDA) Q19020 (/IDA) Q9JHU4 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
4 P34036 (/IDA) Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q14204 (/TAS) Q14204 (/TAS) Q14204 (/TAS)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
3 Q14204 (/NAS) Q14204 (/NAS) Q14204 (/NAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
3 Q14204 (/IDA) Q14204 (/IDA) Q14204 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
3 P34036 (/IDA) P37276 (/IDA) Q19020 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q14204 (/HDA) Q14204 (/HDA) Q14204 (/HDA)
Showing 1 to 10 of 51 entries
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