CATH Superfamily 1.10.8.270
putative rabgap domain of human tbc1 domain family member 14 like domains
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"putative rabgap domain of human tbc1 domain family member 14 like domains
".
FunFam 7: TBC1 domain family member 10A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q4KMP7 (/IPI) Q8IV04 (/IPI) Q9BXI6 (/IPI) Q9BXI6 (/IPI) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | Q8BHL3 (/ISS) Q9VGL8 (/ISS) |
|
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
2 | Q9BXI6 (/IPI) Q9BXI6 (/IPI) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q9BXI6 (/HDA) Q9BXI6 (/HDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q4KMP7 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q8BHL3 (/ISO) |
|
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | P58802 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
|
4 | Q4KMP7 (/IMP) Q8IV04 (/IMP) Q9BXI6 (/IMP) Q9BXI6 (/IMP) |
|
Retrograde transport, endosome to Golgi GO:0042147
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
|
4 | P58802 (/ISO) Q8BHL3 (/ISO) Q8C9V1 (/ISO) Q8C9V1 (/ISO) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
2 | Q8BHL3 (/ISS) Q9VGL8 (/ISS) |
|
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
2 | Q9BXI6 (/IDA) Q9BXI6 (/IDA) |
|
Negative regulation of B cell activation GO:0050869
Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
|
2 | Q8C9V1 (/IGI) Q8C9V1 (/IGI) |
|
Negative regulation of B cell activation GO:0050869
Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
|
2 | Q8C9V1 (/IMP) Q8C9V1 (/IMP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q8C9V1 (/IGI) Q8C9V1 (/IGI) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q8C9V1 (/IMP) Q8C9V1 (/IMP) |
|
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
2 | Q8C9V1 (/IMP) Q8C9V1 (/IMP) |
|
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
|
2 | Q9BXI6 (/IDA) Q9BXI6 (/IDA) |
|
Polarity specification of proximal/distal axis GO:0010085
Any process resulting in the establishment of polarity along the proximal/distal axis.
|
1 | Q9VGL8 (/IMP) |
|
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
|
1 | Q9VGL8 (/HMP) |
|
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
|
1 | Q9VGL8 (/IMP) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q4KMP7 (/IDA) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q8BHL3 (/ISO) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q8IV04 (/TAS) |
|
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | P58802 (/ISO) |
|
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
|
1 | P58802 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q4KMP7 (/IDA) Q8IV04 (/IDA) Q9BXI6 (/IDA) Q9BXI6 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P58802 (/ISO) Q8BHL3 (/ISO) Q8C9V1 (/ISO) Q8C9V1 (/ISO) |
|
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
2 | Q9BXI6 (/TAS) Q9BXI6 (/TAS) |
|
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
|
2 | Q8C9V1 (/ISO) Q8C9V1 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q9BXI6 (/HDA) Q9BXI6 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9VGL8 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8IV04 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8IV04 (/HDA) |
|
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
|
1 | Q9VGL8 (/IDA) |
|
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
|
1 | Q8IV04 (/IDA) |
|
Cytoplasmic side of apical plasma membrane GO:0098592
The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.
|
1 | Q9VGL8 (/IDA) |
|
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
1 | Q8IV04 (/TAS) |
