The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
putative rabgap domain of human tbc1 domain family member 14 like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: GTPase-activating protein GYP3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
7 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) Q12317 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
6 P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
7 P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) Q12317 (/IGI)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
7 P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) P48566 (/IGI) Q12317 (/IGI)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
7 P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) Q12317 (/IPI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
6 P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
6 P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
6 P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
6 P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI) P48566 (/IPI)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
6 P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP) P48566 (/IMP)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Incipient cellular bud site GO:0000131
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
7 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) Q12317 (/IDA)
Polarisome GO:0000133
Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
7 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) Q12317 (/IDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
7 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) Q12317 (/IDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
6 P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
6 P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
6 P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA) P48566 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
6 P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA) P48566 (/HDA)
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