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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Taxadiene 5-alpha hydroxylase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-amyrin 28-monooxygenase. [EC: 1.14.14.126]
Beta-amyrin + 3 O(2) + 3 [reduced NADPH--hemoprotein reductase] = oleanolate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro.
  • The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively.
  • The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyze the reaction to completion, resulting in accumulation of both intermediates.
  • Formerly EC 1.14.13.201.
 7 A0A396GTM4 A0A396GTM4 A5BFI4 F6H9N6 I7C6E8 Q2MJ20 Q2MJ20
Dammarenediol 12-hydroxylase. [EC: 1.14.14.120]
Dammarenediol-II + [reduced NADPH--hemoprotein reductase] + O(2) = protopanaxadiol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from ginseng (Panax ginseng).
  • Involved in the biosynthetic pathway of ginsenosides.
  • Formerly EC 1.14.13.183.
 1 H2DH16
Taxoid 7-beta-hydroxylase. [EC: 1.14.13.147]
Taxusin + O(2) + NADPH = 7-beta-hydroxytaxusin + NADP(+) + H(2)O.
  • Requires cytochrome P450.
  • From the yew tree Taxus cuspidata.
  • Does not act on earlier intermediates in taxol biosynthesis.
 1 Q6JTJ0
Taxoid 14-beta-hydroxylase. [EC: 1.14.13.146]
10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate + O(2) + NADPH = 10-beta,14-beta-dihydroxytaxa-4(20),11-dien-5?-yl acetate + NADP(+) + H(2)O.
  • Requires cytochrome P450.
  • From the yew Taxus cuspidata.
  • Also acts on taxa-4(20),11-dien-5-alpha-yl acetate.
 1 Q84KI1
Protopanaxadiol 6-hydroxylase. [EC: 1.14.14.121]
Protopanaxadiol + [reduced NADPH--hemoprotein reductase] + O(2) = protopanaxatriol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from the rhizomes of ginseng (Panax ginseng).
  • Involved in the biosynthetic pathway of ginsenosides.
  • Formerly EC 1.14.13.184.
 1 I7CT85
(+)-abscisic acid 8'-hydroxylase. [EC: 1.14.14.137]
(+)-abscisate + [reduced NADPH--hemoprotein reductase] + O(2) = 8'-hydroxyabscisate + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Catalyzes the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone.
  • CO inhibits the reaction, but its effects can be reversed by the presence of blue light.
  • The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.
  • Formerly EC 1.14.13.93.
 1 O81077
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