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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 185: Fatty-acid peroxygenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fatty-acid peroxygenase. [EC: 1.11.2.4]
Fatty acid + H(2)O(2) = 3- or 2-hydroxy fatty acid + H(2)O.
  • A cytosolic heme-thiolate protein with sequence homology to P450 monooxygenases.
  • Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function.
  • Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis).
  • Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalyzed by the common P450s.
  • A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated.
  • Oxidizes the peroxidase substrate 3,3,5,5-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.
 16 A0A164W6Q6 A0A164W6Q6 A0A164W6Q6 A0A164W6Q6 A0A1D8FGJ4 A0A1D8FGJ4 A0A1D8FGJ4 A0A1D8FGJ4 L8ABW4 L8ABW4
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