The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 84: Interferon-induced with helicase C domain 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | A0A0E3D804 (/IGI) A0A0K0K5Q0 (/IGI) A0A2R8QBG0 (/IGI) F1R4B9 (/IGI) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | A0A0E3D804 (/IPI) A0A0K0K5Q0 (/IPI) A0A2R8QBG0 (/IPI) F1R4B9 (/IPI) |
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
3 | A0A060VZM9 (/IDA) D7F7W8 (/IDA) Q9BYX4 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q8R5F7 (/IPI) Q8R5F7 (/IPI) Q9BYX4 (/IPI) |
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
1 | Q9BYX4 (/TAS) |
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
1 | Q9BYX4 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9BYX4 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9BYX4 (/IPI) |
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
1 | Q9BYX4 (/IPI) |
There are 47 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A0A0E3D804 (/IDA) A0A0K0K5Q0 (/IDA) A0A2R8QBG0 (/IDA) F1R4B9 (/IDA) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A0A0E3D804 (/IGI) A0A0K0K5Q0 (/IGI) A0A2R8QBG0 (/IGI) F1R4B9 (/IGI) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
4 | A0A060VZM9 (/IMP) D7F7W8 (/IMP) Q8R5F7 (/IMP) Q8R5F7 (/IMP) |
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
2 | Q8R5F7 (/IMP) Q8R5F7 (/IMP) |
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Immune response involved in response to exogenous dsRNA GO:1902615
Any immune response that is involved in response to exogenous dsRNA.
|
2 | A0A060VZM9 (/IMP) D7F7W8 (/IMP) |
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
2 | Q8R5F7 (/ISO) Q8R5F7 (/ISO) |
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
2 | Q8R5F7 (/ISS) Q8R5F7 (/ISS) |
Detection of virus GO:0009597
The series of events in which a stimulus from a virus is received and converted into a molecular signal.
|
1 | Q9BYX4 (/TAS) |
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | Q9BYX4 (/TAS) |
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
1 | Q9BYX4 (/TAS) |
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | Q9BYX4 (/IDA) |
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | Q9BYX4 (/TAS) |
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
|
1 | Q9BYX4 (/IMP) |
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
|
1 | Q9BYX4 (/TAS) |
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
1 | Q9BYX4 (/IDA) |
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
1 | Q9BYX4 (/IMP) |
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
1 | Q9BYX4 (/TAS) |
Regulation of type III interferon production GO:0034344
Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.
|
1 | Q9BYX4 (/TAS) |
Positive regulation of interferon-beta secretion GO:0035549
Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.
|
1 | Q9BYX4 (/IMP) |
Cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528
Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
1 | Q9BYX4 (/TAS) |
MDA-5 signaling pathway GO:0039530
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
1 | Q9BYX4 (/IDA) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q9BYX4 (/TAS) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q9BYX4 (/IDA) |
Positive regulation of response to cytokine stimulus GO:0060760
Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
|
1 | Q9BYX4 (/IMP) |
Cellular response to exogenous dsRNA GO:0071360
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
1 | Q9BYX4 (/IMP) |
Positive regulation of interferon-alpha secretion GO:1902741
Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion.
|
1 | Q9BYX4 (/IMP) |
Positive regulation of tumor necrosis factor secretion GO:1904469
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion.
|
1 | Q9BYX4 (/IMP) |
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
|
1 | Q9BYX4 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | A0A060VZM9 (/IDA) D7F7W8 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9BYX4 (/TAS) |