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CATH Superfamily 1.10.533.10

Death Domain, Fas

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 153: Caspase-8

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Caspase-8. [EC: 3.4.22.61]
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).
  • Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
  • Apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation.
  • Contains two tandem death effector domains (DEDs) in its N-terminal prodomain, which play a role in procaspase activation.
  • Linked to cell surface death receptors such as Fas.
  • When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated.
  • Has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala at the P1' position.
  • Has very broad P4 specificity, tolerating substrates with Asp, Val or Leu in this position.
  • Endogenous substrates for caspase-8 include procaspase-3, the pro- apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8 activity modulator FLIP(L).
  • Belongs to peptidase family C14.
 4 O89110 O89110 Q3U607 Q3U607
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