The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 90: Dual specificity mitogen-activated protein kinase ...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 F1LP57 (/IPI) P45985 (/IPI) P45985 (/IPI) P45985 (/IPI) P45985 (/IPI) P45985 (/IPI) P45985 (/IPI) P45985 (/IPI) P47809 (/IPI) P47809 (/IPI)
(4 more)
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
9 O61444 (/TAS) O62602 (/TAS) O62602 (/TAS) O62602 (/TAS) Q7KPK6 (/TAS) Q7KPX5 (/TAS) Q7KPX5 (/TAS) Q7KPX5 (/TAS) Q9U983 (/TAS)
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
8 F1LP57 (/IDA) O62602 (/IDA) O62602 (/IDA) O62602 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q9U983 (/IDA)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
8 F1LP57 (/IPI) O62602 (/IPI) O62602 (/IPI) O62602 (/IPI) Q4KSH6 (/IPI) Q4KSH6 (/IPI) Q4KSH6 (/IPI) Q9U983 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
7 P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
4 O62602 (/IDA) O62602 (/IDA) O62602 (/IDA) Q9U983 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
JUN kinase kinase activity GO:0008545
Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
JUN kinase kinase activity GO:0008545
Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
9 F1LP57 (/IDA) O61444 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q7KPK6 (/IDA) Q7KPX5 (/IDA) Q7KPX5 (/IDA) Q7KPX5 (/IDA)
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
9 O61444 (/IGI) O62602 (/IGI) O62602 (/IGI) O62602 (/IGI) Q7KPK6 (/IGI) Q7KPX5 (/IGI) Q7KPX5 (/IGI) Q7KPX5 (/IGI) Q9U983 (/IGI)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
7 P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
7 P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
7 P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
7 P45985 (/IEP) P45985 (/IEP) P45985 (/IEP) P45985 (/IEP) P45985 (/IEP) P45985 (/IEP) P45985 (/IEP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
5 O61444 (/IGI) Q7KPK6 (/IGI) Q7KPX5 (/IGI) Q7KPX5 (/IGI) Q7KPX5 (/IGI)
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
5 A4FVH5 (/IMP) B1NA68 (/IMP) D6RRB5 (/IMP) F1RDF6 (/IMP) Q1JPX6 (/IMP)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
5 O61444 (/IMP) Q7KPK6 (/IMP) Q7KPX5 (/IMP) Q7KPX5 (/IMP) Q7KPX5 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
4 O62602 (/IDA) O62602 (/IDA) O62602 (/IDA) Q9U983 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
4 O62602 (/IDA) O62602 (/IDA) O62602 (/IDA) Q9U983 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 O62602 (/IGI) O62602 (/IGI) O62602 (/IGI) Q9U983 (/IGI)
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
4 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP) Q9U983 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Oocyte axis specification GO:0007309
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
4 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP) Q9U983 (/IMP)
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
4 O62602 (/NAS) O62602 (/NAS) O62602 (/NAS) Q9U983 (/NAS)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
4 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP) Q9U983 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
4 F1LP57 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
4 F1LP57 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
4 F1LP57 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
4 O62602 (/IGI) O62602 (/IGI) O62602 (/IGI) Q9U983 (/IGI)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
4 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP) Q9U983 (/IMP)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
4 F1LP57 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
4 F1LP57 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP) Q4KSH6 (/IMP)
Cellular response to sorbitol GO:0072709
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.
4 F1LP57 (/IEP) Q4KSH6 (/IEP) Q4KSH6 (/IEP) Q4KSH6 (/IEP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 P47809 (/IPI) P47809 (/IPI) P47809 (/IPI)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
3 P47809 (/IMP) P47809 (/IMP) P47809 (/IMP)
Positive regulation of smooth muscle cell apoptotic process GO:0034393
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
3 P47809 (/IDA) P47809 (/IDA) P47809 (/IDA)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
3 O62602 (/IMP) O62602 (/IMP) O62602 (/IMP)
Negative regulation of motor neuron apoptotic process GO:2000672
Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.
3 P47809 (/IMP) P47809 (/IMP) P47809 (/IMP)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
2 A4UU31 (/IMP) B3DHI6 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P45985 (/TAS) P47809 (/TAS) P47809 (/TAS) P47809 (/TAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
9 F1LP57 (/IDA) O61444 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q7KPK6 (/IDA) Q7KPX5 (/IDA) Q7KPX5 (/IDA) Q7KPX5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O62602 (/ISS) O62602 (/ISS) O62602 (/ISS) Q9U983 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
4 F1LP57 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA) Q4KSH6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
3 P47809 (/ISO) P47809 (/ISO) P47809 (/ISO)
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