The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 109: Ribosomal protein S6 kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | O75582 (/IPI) O75582 (/IPI) O75582 (/IPI) O75582 (/IPI) O75676 (/IPI) Q8C050 (/IPI) Q9V3I5 (/IPI) Q9V3I5 (/IPI) Q9Z2B9 (/IPI) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
8 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
6 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
4 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | Q5R4K3 (/ISS) Q9V3I5 (/ISS) Q9V3I5 (/ISS) Q9Z2B9 (/ISS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Histone kinase activity (H3-S10 specific) GO:0035175
Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Histone kinase activity (H3-S10 specific) GO:0035175
Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.
|
2 | Q9V3I5 (/TAS) Q9V3I5 (/TAS) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q8C050 (/ISO) |
Ribosomal protein S6 kinase activity GO:0004711
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
|
1 | O75676 (/NAS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q9Z2B9 (/ISS) |
There are 52 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
8 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
7 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75676 (/TAS) Q9V3I5 (/TAS) Q9V3I5 (/TAS) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) |
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
6 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
6 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) |
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
5 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75676 (/TAS) |
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
|
5 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75676 (/TAS) |
Positive regulation of histone phosphorylation GO:0033129
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75676 (/IMP) |
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
4 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) |
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
4 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
4 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) |
Histone H2A-S1 phosphorylation GO:0043990
The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.
|
4 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
4 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) |
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
|
3 | Q5R4K3 (/ISS) Q8C050 (/ISS) Q9Z2B9 (/ISS) |
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
|
3 | Q5R4K3 (/ISS) Q8C050 (/ISS) Q9Z2B9 (/ISS) |
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
2 | Q9V3I5 (/TAS) Q9V3I5 (/TAS) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q5R4K3 (/ISS) Q9Z2B9 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Female meiosis chromosome segregation GO:0016321
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
|
2 | Q9V3I5 (/HMP) Q9V3I5 (/HMP) |
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Negative regulation of chromatin silencing GO:0031936
Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Positive regulation of histone phosphorylation GO:0033129
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Histone H2A-S1 phosphorylation GO:0043990
The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.
|
2 | Q5R4K3 (/ISS) Q8C050 (/ISS) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q5R4K3 (/ISS) Q8C050 (/ISS) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
2 | Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | Q5R4K3 (/ISS) Q8C050 (/ISS) |
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
|
2 | Q9V3I5 (/IMP) Q9V3I5 (/IMP) |
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9Z2B9 (/ISS) |
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
1 | Q8C050 (/ISO) |
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q9Z2B9 (/ISS) |
Histone H2A-S1 phosphorylation GO:0043990
The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.
|
1 | Q8C050 (/ISO) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8C050 (/ISO) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | Q8C050 (/ISO) |
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | O75676 (/TAS) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
7 | A0A0A6YYC0 (/IDA) E9PJN1 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75676 (/IDA) Q8C050 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) O75582 (/IMP) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) O75582 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) O75582 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | A0A0A6YYC0 (/IDA) E9PJN1 (/IDA) O75676 (/IDA) |
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
|
2 | Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9V3I5 (/HDA) Q9V3I5 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q5R4K3 (/ISS) Q9Z2B9 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q8C050 (/ISO) Q9Z2B9 (/ISO) |
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
2 | Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
|
2 | Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
|
2 | Q9V3I5 (/IDA) Q9V3I5 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q5R4K3 (/ISS) Q8C050 (/ISS) |
X chromosome located dosage compensation complex, transcription activating GO:0016456
An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.
|
2 | Q9V3I5 (/IPI) Q9V3I5 (/IPI) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8C050 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9Z2B9 (/ISO) |